ISSN |
1948-0210 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Sport Sciences |
Manuscript Type |
Minireviews |
Article Title |
Advanced glycation end productions and tendon stem/progenitor cells in the pathogenesis of diabetic tendinopathy
|
Manuscript Source |
Invited Manuscript |
All Author List |
Liu Shi, Pan-Pan Lu, Guang-Chun Dai, Ying-Juan Li and Yun-Feng Rui |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81572187 |
National Natural Science Foundation of China |
81871812 |
Jiangsu Provincial Medical Talent, The Project of Invigorating Health Care through Science, Technology and Education |
ZDRCA2016083 |
Natural Science Foundation of Jiangsu Province for Young Scholars, China |
BK20200398 |
Entrepreneurship and innovation program of Jiangsu Province, China |
1190000054 |
The Six Projects Sponsoring Talent Summits of Jiangsu Province, China |
LGY2017099 |
|
Corresponding Author |
Yun-Feng Rui, MD, PhD, Deputy Director, Professor, Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing 210009, Jiangsu Province, China. ruiyunfeng@126.com |
Key Words |
Tendinopathy; Diabetes mellitus; Tendon stem/progenitor cells; Advanced glycation end products |
Core Tip |
Patients with diabetic tendinopathy usually suffer from chronic pain, restricted joint motion, calcium deposition, and even tendon rupture. Advanced glycation end products (AGEs) have been shown to affect tendon biology and biomechanical properties. In addition, tendon-derived stem/progenitor cells (TSPCs) play an important role in tendon hemostasis, regeneration and repair. However, the relationships between diabetic tendinopathy, AGEs and TSPCs remain unclear. Thus, in this review, we summarized the current findings and discussed the possible relationships between AGEs and TSPCs. This might provide new guidance for the development of effective treatments for diabetic tendinopathy. |
Publish Date |
2021-09-18 09:35 |
Citation |
Shi L, Lu PP, Dai GC, Li YJ, Rui YF. Advanced glycation end productions and tendon stem/progenitor cells in the pathogenesis of diabetic tendinopathy. World J Stem Cells 2021; 13(9): 1338-1348 |
URL |
https://www.wjgnet.com/1948-0210/full/v13/i9/1338.htm |
DOI |
https://dx.doi.org/10.4252/wjsc.v13.i9.1338 |