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12/15/2021 9:38:23 AM | Browse: 349 | Download: 645
Publication Name World Journal of Psychiatry
Manuscript ID 65781
Country Slovenia
Received
2021-03-16 20:18
Peer-Review Started
2021-03-16 20:53
To Make the First Decision
Return for Revision
2021-05-05 02:03
Revised
2021-05-25 12:17
Second Decision
2021-09-14 03:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-17 02:53
Articles in Press
2021-09-17 02:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-11-06 04:40
Typeset the Manuscript
2021-12-03 12:26
Publish the Manuscript Online
2021-12-15 09:38
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Case Control Study
Article Title BDNF methylation and mRNA expression in brain and blood of completed suicides in Slovenia
Manuscript Source Invited Manuscript
All Author List Sandra Ropret, Katarina Kouter, Tomaž Zupanc and Alja Videtic Paska
ORCID
Author(s) ORCID Number
Sandra Ropret http://orcid.org/0000-0001-8841-2648
Katarina Kouter http://orcid.org/0000-0002-1051-959X
Tomaž Zupanc http://orcid.org/0000-0002-7943-7867
Alja Videtic Paska http://orcid.org/0000-0002-1182-5417
Funding Agency and Grant Number
Funding Agency Grant Number
Slovenian Research Agency P1-0390
Slovenian Research Agency J3-7132
Corresponding Author Alja Videtic Paska, PhD, Associate Professor, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana SI-1000, Slovenia. alja.videtic@mf.uni-lj.si
Key Words Suicidal behavior; Epigenetics; Next-generation sequencing; Brain; Blood; Caucasian
Core Tip BDNF methylation analysis of brain tissues did not show differences between control subjects and suicide victims, although there was higher expression of BDNF transcript I-IX in Brodmann area 9 of the suicide victims. Furthermore, the data obtained from blood are interesting, especially in terms of the direction of the effects, although due to the extensively degraded blood RNA, we were not able to confirm these effects on mRNA expression. Although suicide is a multifactorial disorder, our data overall further support the previously implicated role of BDNF in suicidality.
Publish Date 2021-12-15 09:38
Citation Ropret S, Kouter K, Zupanc T, Videtic Paska A. BDNF methylation and mRNA expression in brain and blood of completed suicides in Slovenia. World J Psychiatr 2021; 11(12): 1301-1313
URL https://www.wjgnet.com/2220-3206/full/v11/i12/1301.htm
DOI https://dx.doi.org/10.5498/wjp.v11.i12.1301
Full Article (PDF) WJP-11-1301.pdf
Full Article (Word) WJP-11-1301.docx
Manuscript File 65781-Review-Filipodia.docx
Answering Reviewers 65781-Answering reviewers.pdf
Audio Core Tip 65781-Audio core tip.m4a
Biostatistics Review Certificate 65781-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 65781-Conflict-of-interest statement.pdf
Copyright License Agreement 65781-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 65781-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 65781-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 65781-Language certificate.pdf
Supplementary Material 65781-Supplementary material.pdf
Peer-review Report 65781-Peer-review(s).pdf
Scientific Misconduct Check 65781-Bing-Fan JR-2.png
Scientific Editor Work List 65781-Scientific editor work list.pdf