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Articles Published Processes
2/25/2022 12:19:16 PM | Browse: 308 | Download: 632
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Received |
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2021-03-16 11:34 |
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Peer-Review Started |
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2021-03-16 12:16 |
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To Make the First Decision |
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Return for Revision |
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2021-05-05 05:05 |
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Revised |
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2021-05-19 06:08 |
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Second Decision |
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2022-02-18 05:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-20 13:34 |
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Articles in Press |
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2022-02-20 13:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-02-14 08:45 |
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Typeset the Manuscript |
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2022-02-22 01:41 |
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Publish the Manuscript Online |
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2022-02-25 12:19 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Abnormal lipid synthesis as a therapeutic target for cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Yu Wang, Qin-Chao Hu, Tong Wu, Juan Xia, Xiao-An Tao and Bin Cheng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82001044, 81630025 |
| China Postdoctoral Science Foundation |
2020M673019 |
| Guangdong Basic and Applied Basic Research Foundation |
2019A1515110071 |
| Natural Science Foundation of Guangdong Province |
2017A030311033 |
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| Corresponding Author |
Bin Cheng, MD, PhD, Dean, Department of Oral Medicine, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuanxi Road, Guangzhou 510000, Guangdong Province, China. chengbin@mail.sysu.edu.cn |
| Key Words |
Lipid synthesis; Cancer stem cells; Anti-cancer therapy; Stem cell survival; Lipid anabolism |
| Core Tip |
Cancer stem cells (CSCs) are associated with the occurrence, metastasis, therapy resistance, and relapse of cancer. CSCs are highly dependent on lipid metabolism to maintain stemness and satisfy the requirements of biosynthesis and energy metabolism. Here, we review the molecular mechanism underlying the relationship between lipid synthesis and stem cell survival, the signal transduction pathways involved, and the application prospect of lipid synthesis reprogramming in CSC therapy. We demonstrate that lipid anabolism alterations promote the survival of CSCs. |
| Publish Date |
2022-02-25 12:19 |
| Citation |
Wang SY, Hu QC, Wu T, Xia J, Tao XA, Cheng B. Abnormal lipid synthesis as a therapeutic target for cancer stem cells. World J Stem Cells 2022; 14(2): 146-162 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i2/146.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i2.146 |
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