Publication Name	World Journal of Stem Cells
Manuscript ID	65802
Country	China

Received	2021-03-16 11:34
Peer-Review Started	2021-03-16 12:16
To Make the First Decision
Return for Revision	2021-05-05 05:05
Revised	2021-05-19 06:08
Second Decision	2022-02-18 05:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-20 13:34
Articles in Press	2022-02-20 13:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-02-14 08:45
Typeset the Manuscript	2022-02-22 01:41
Publish the Manuscript Online	2022-02-25 12:19

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Abnormal lipid synthesis as a therapeutic target for cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	Si-Yu Wang, Qin-Chao Hu, Tong Wu, Juan Xia, Xiao-An Tao and Bin Cheng
ORCID	Author(s) ORCID Number Si-Yu Wang http://orcid.org/0000-0001-9690-5514 Qin-Chao Hu http://orcid.org/0000-0002-4969-0589 Tong Wu http://orcid.org/0000-0001-7455-9083 Juan Xia http://orcid.org/0000-0002-4966-7119 Xiao-An Tao http://orcid.org/0000-0003-1114-9698 Bin Cheng http://orcid.org/0000-0001-7288-806X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82001044, 81630025 China Postdoctoral Science Foundation 2020M673019 Guangdong Basic and Applied Basic Research Foundation 2019A1515110071 Natural Science Foundation of Guangdong Province 2017A030311033
Corresponding Author	Bin Cheng, MD, PhD, Dean, Department of Oral Medicine, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuanxi Road, Guangzhou 510000, Guangdong Province, China. chengbin@mail.sysu.edu.cn
Key Words	Lipid synthesis; Cancer stem cells; Anti-cancer therapy; Stem cell survival; Lipid anabolism
Core Tip	Cancer stem cells (CSCs) are associated with the occurrence, metastasis, therapy resistance, and relapse of cancer. CSCs are highly dependent on lipid metabolism to maintain stemness and satisfy the requirements of biosynthesis and energy metabolism. Here, we review the molecular mechanism underlying the relationship between lipid synthesis and stem cell survival, the signal transduction pathways involved, and the application prospect of lipid synthesis reprogramming in CSC therapy. We demonstrate that lipid anabolism alterations promote the survival of CSCs.
Publish Date	2022-02-25 12:19
Citation	Wang SY, Hu QC, Wu T, Xia J, Tao XA, Cheng B. Abnormal lipid synthesis as a therapeutic target for cancer stem cells. World J Stem Cells 2022; 14(2): 146-162
URL	https://www.wjgnet.com/1948-0210/full/v14/i2/146.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i2.146

Full Article (PDF)	WJSC-14-146.pdf
Full Article (Word)	WJSC-14-146.docx
Manuscript File	65802_Auto_Edited-JJW-WangTQ.docx
Answering Reviewers	65802-Answering reviewers.pdf
Audio Core Tip	65802-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65802-Conflict-of-interest statement.pdf
Copyright License Agreement	65802-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65802-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	65802-Language certificate.pdf
Peer-review Report	65802-Peer-review(s).pdf
Scientific Misconduct Check	65802-Bing-Wang JJ-2.png
Scientific Editor Work List	65802-Scientific editor work list.pdf