Publication Name	World Journal of Stem Cells
Manuscript ID	65857
Country	Germany

Received	2021-03-16 20:49
Peer-Review Started	2021-03-16 20:58
To Make the First Decision
Return for Revision	2021-05-05 04:55
Revised	2021-05-25 19:02
Second Decision	2021-08-06 03:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-06 08:15
Articles in Press	2021-08-06 08:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-08-19 01:58
Publish the Manuscript Online	2021-08-20 05:46

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Review
Article Title	Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia
Manuscript Source	Invited Manuscript
All Author List	Wen-Qiang Xin, Wei Wei, Yong-Li Pan, Bao-Long Cui, Xin-Yu Yang, Mathias Bähr and Thorsten R Doeppner
ORCID	Author(s) ORCID Number Wen-Qiang Xin http://orcid.org/0000-0003-0231-6474 Wei Wei http://orcid.org/0000-0001-7843-6697 Yong-Li Pan http://orcid.org/0000-0003-0473-3773 Bao-Long Cui http://orcid.org/0000-0002-9720-2527 Xin-Yu Yang http://orcid.org/0000-0002-2194-4137 Mathias Bähr http://orcid.org/0000-0002-9570-1592 Thorsten R Doeppner http://orcid.org/0000-0002-1222-9211
Funding Agency and Grant Number
Corresponding Author	Thorsten R Doeppner, MD, MSc, Professor, Department of Neurology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany. thorsten.doeppner@med.uni-goettingen.de
Key Words	Extracellular vesicles; Mesenchymal stem cells; Microglial activation; M2 polarization; Ischemic stroke
Core Tip	Upon stroke induction, M1 microglia participate in the proinflammatory tissue response, whereas M2 microglia promote brain repair by secreting anti-inflammatory cytokines and neurotrophic factors. This review summarizes the effects of mesenchymal stem cells (MSCs) and MSC-extracellular vesicles on regulating microglial activity under ischemic stroke conditions through various signaling pathways, such as cytokines, neurotrophic factors, transcription factors, and microRNAs.
Publish Date	2021-08-20 05:46
Citation	Xin WQ, Wei W, Pan YL, Cui BL, Yang XY, Bähr M, Doeppner TR. Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia. World J Stem Cells 2021; 13(8): 1030-1048
URL	https://www.wjgnet.com/1948-0210/full/v13/i8/1030.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i8.1030

Full Article (PDF)	WJSC-13-1030.pdf
Full Article (Word)	WJSC-13-1030.docx
Manuscript File	65857_Auto_Edited-JPY.docx
Answering Reviewers	65857-Answering reviewers.pdf
Audio Core Tip	65857-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65857-Conflict-of-interest statement.pdf
Copyright License Agreement	65857-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65857-Language certificate.pdf
Peer-review Report	65857-Peer-review(s).pdf
Scientific Misconduct Check	65857-Scientific misconduct check.pdf
Scientific Editor Work List	65857-Scientific editor work list.pdf
CrossCheck Report	65857-CrossCheck report.pdf