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Articles Published Processes
8/20/2021 5:46:25 AM | Browse: 748 | Download: 1848
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Received |
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2021-03-16 20:49 |
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Peer-Review Started |
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2021-03-16 20:58 |
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First Decision by Editorial Office Director |
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2021-05-05 04:55 |
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Return for Revision |
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2021-05-05 04:55 |
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Revised |
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2021-05-25 19:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-08-06 03:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-08-06 08:15 |
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Articles in Press |
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2021-08-06 08:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-08-19 01:58 |
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Publish the Manuscript Online |
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2021-08-20 05:46 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Review |
| Article Title |
Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Qiang Xin, Wei Wei, Yong-Li Pan, Bao-Long Cui, Xin-Yu Yang, Mathias Bähr and Thorsten R Doeppner |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Thorsten R Doeppner, MD, MSc, Professor, Department of Neurology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany. thorsten.doeppner@med.uni-goettingen.de |
| Key Words |
Extracellular vesicles; Mesenchymal stem cells; Microglial activation; M2 polarization; Ischemic stroke |
| Core Tip |
Upon stroke induction, M1 microglia participate in the proinflammatory tissue response, whereas M2 microglia promote brain repair by secreting anti-inflammatory cytokines and neurotrophic factors. This review summarizes the effects of mesenchymal stem cells (MSCs) and MSC-extracellular vesicles on regulating microglial activity under ischemic stroke conditions through various signaling pathways, such as cytokines, neurotrophic factors, transcription factors, and microRNAs. |
| Publish Date |
2021-08-20 05:46 |
| Citation |
Xin WQ, Wei W, Pan YL, Cui BL, Yang XY, Bähr M, Doeppner TR. Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia. World J Stem Cells 2021; 13(8): 1030-1048 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i8/1030.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i8.1030 |
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