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Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 483 | Download: 1391
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Received |
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2021-03-17 12:30 |
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Peer-Review Started |
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2021-03-17 12:35 |
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First Decision by Editorial Office Director |
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2021-04-19 02:39 |
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Return for Revision |
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2021-04-19 02:39 |
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Revised |
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2021-04-20 04:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-09-09 03:22 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-09-10 09:23 |
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Articles in Press |
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2021-09-10 09:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-09 08:11 |
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Publish the Manuscript Online |
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2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Editorial |
| Article Title |
Inhibition of poly (ADP-Ribose) polymerase: A promising strategy targeting pancreatic cancer with BRCAness phenotype
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keun-Yeong Jeong and Haejun Lee |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Keun-Yeong Jeong, PhD, Executive Vice President, Research Assistant Professor, R&D Center, Metimedi Pharmaceuticals, 263 Central ro, Incheon 22006, South Korea. alvirus@naver.com |
| Key Words |
Pancreatic cancer; BRCAness; Poly (ADP-Ribose) polymerase-1; PARylation; Poly (ADP-Ribose) polymerase-1 inhibitor |
| Core Tip |
The incidence of germline mutations of the breast cancer susceptibility gene (BRCA), defined as BRCAness, that can be targeted for pancreatic cancer is 9%-17%. Mutations in BRCAs are responsible for causing genetic instability and worsening the prognosis. Therefore, inhibition of poly (ADP-Ribose) polymerase-1 has emerged as a promising therapeutic target for BRCAness pancreatic cancer within the framework of an increase in genome instability. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Jeong KY, Lee H. Inhibition of poly (ADP-Ribose) polymerase: A promising strategy targeting pancreatic cancer with BRCAness phenotype. World J Gastrointest Oncol 2021; 13(11): 1544-1550 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1544.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1544 |
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