Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	65963
Country	Italy

Received	2021-03-18 13:41
Peer-Review Started	2021-03-18 13:47
To Make the First Decision
Return for Revision	2021-07-16 01:49
Revised	2021-08-01 14:20
Second Decision	2022-01-06 03:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-06 19:11
Articles in Press	2022-01-06 19:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-01 23:42
Typeset the Manuscript	2022-01-25 16:52
Publish the Manuscript Online	2022-02-10 14:26

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Minireviews
Article Title	Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy
Manuscript Source	Invited Manuscript
All Author List	Paola De Nardi, Alessandro Giani, Giulia Maggi and Marco Braga
ORCID	Author(s) ORCID Number Paola De Nardi http://orcid.org/0000-0002-9337-6765 Alessandro Giani http://orcid.org/0000-0003-0718-2321 Giulia Maggi http://orcid.org/0000-0001-5774-6020 Marco Braga http://orcid.org/0000-0002-5009-9710
Funding Agency and Grant Number
Corresponding Author	Paola De Nardi, FASCRS, Staff Physician, Surgeon, Department of Gastrointestinal Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milano 20132, Italy. denardi.paola@hsr.it
Key Words	Advanced rectal cancer; Sarcopenia; Neoadjuvant treatment; Chemo-radiotherapy; Surgery; Muscle mass change; Prognosis; Survival; Review
Core Tip	Rectal cancer is one of the most common cancer worldwide. The present review explores the potential prognostic role of muscle depletion in patients undergoing curative surgery for rectal cancer after neoadjuvant treatment. Evidence supports the hypothesis that sarcopenic patients, and patients in whom a decrement in muscle mass is detected during neoadjuvant treatment, are deemed to greater risk of tumor recurrence and tumor death. Despite this observation, assessment of muscle mass is mostly neglected, while it could inform on prognosis as well as guide optimal treatment.
Publish Date	2022-02-10 14:26
Citation	De Nardi P, Giani A, Maggi G, Braga M. Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy. World J Gastrointest Oncol 2022; 14(2): 423-433
URL	https://www.wjgnet.com/1948-5204/full/v14/i2/423.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i2.423

Full Article (PDF)	WJGO-14-423.pdf
Full Article (Word)	WJGO-14-423.docx
Manuscript File	65963_Auto_Edited-JRF-Filipodia CL.docx
Answering Reviewers	65963-Answering reviewers.pdf
Audio Core Tip	65963-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65963-Conflict-of-interest statement.pdf
Copyright License Agreement	65963-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65963-Language certificate.pdf
Peer-review Report	65963-Peer-review(s).pdf
Scientific Misconduct Check	65963-Bing-Wang JL-1.jpg
Scientific Misconduct Check	65963-Bing-Fan JR-2.png
Scientific Editor Work List	65963-Scientific editor work list.pdf