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Articles Published Processes
10/21/2021 8:44:04 AM | Browse: 425 | Download: 988
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Received |
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2021-03-22 06:12 |
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Peer-Review Started |
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2021-03-22 06:19 |
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To Make the First Decision |
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Return for Revision |
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2021-07-05 09:47 |
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Revised |
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2021-07-13 12:37 |
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Second Decision |
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2021-08-13 02:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-13 03:33 |
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Articles in Press |
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2021-08-13 03:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-09 03:32 |
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Typeset the Manuscript |
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2021-10-18 00:58 |
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Publish the Manuscript Online |
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2021-10-21 08:44 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Long-term survival of a patient with pancreatic cancer and lung metastasis with rare gene alterations after resection and apatinib therapy: a case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Wei Yang, Lin Yang, Hai-Zhen Lu and Yong-Kun Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wu Jieping Medical Foundation |
320.6750.2020-10-95 |
| Sanming Project of Medicine in Shenzhen |
SZSM202011010 |
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| Corresponding Author |
Yong-Kun Sun, MD, Professor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. hsunyk@cicams.ac.cn |
| Key Words |
Pancreatic cancer; BAP1 mutation; PIK3CA mutation; Raf1 fusion; Apatinib; Case report |
| Core Tip |
We reported that a patient with pancreatic ductal adenocarcinoma (PDAC) possessing exceptionally rare RAF1, BAP1 and PIK3CA gene alterations achieved partial responses to apatinib combination therapy twice and experienced long-term survival. Until now, there have been no reports of a long-term PDAC patient with RAF1, BAP1 and PIK3CA aberrations who did not also have K-Ras, TP53, p16/CDKN2A, or SMAD4 gene alterations. In such a rare case, we presume that PDAC with this special genetic alteration pattern may be converted to a kind of “indolent cancer”, which presents fewer symptoms and indicates a good prognosis for pancreatic cancer patients. |
| Publish Date |
2021-10-21 08:44 |
| Citation |
Yang WW, Yang L, Lu HZ, Sun YK. Long-term survival of a patient with pancreatic cancer and lung metastasis: A case report and review of literature. World J Clin Cases 2021; 9(30): 9134-9143 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i30/9134.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i30.9134 |
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