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Articles Published Processes
8/5/2021 2:37:04 PM | Browse: 466 | Download: 917
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Received |
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2021-03-18 20:31 |
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Peer-Review Started |
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2021-03-18 20:36 |
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To Make the First Decision |
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Return for Revision |
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2021-06-06 12:21 |
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Revised |
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2021-06-14 08:11 |
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Second Decision |
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2021-07-05 12:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-05 13:14 |
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Articles in Press |
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2021-07-05 13:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-10 21:29 |
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Typeset the Manuscript |
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2021-08-02 00:44 |
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Publish the Manuscript Online |
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2021-08-05 14:37 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Case Control Study |
| Article Title |
Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lorena Elena Meliț, Cristina Oana Mărginean, Maria Oana Săsăran, Simona Mocan, Dana Valentina Ghiga, Alina Bogliş and Carmen Duicu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Târgu Mureș, Romania |
293/6/14.01.2020 |
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| Corresponding Author |
Cristina Oana Mărginean, MD, PhD, Professor, Department of Pediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Gheorghe Marinescu Street No. 38, Targu Mures 540136, Romania. marginean.oana@gmail.com |
| Key Words |
Innate immunity; Helicobacter pylori infection; Children; Chronic gastritis; TLR9; Systemic inflammation |
| Core Tip |
Environmental factors, such as poor living conditions and rural area might result in an increased risk for Helicobacter pylori (H. pylori) chronic gastritis in children. Serological and rapid urease tests could be used as reliable tests for the detection of H. pylori infection in children. Moreover, leukocytes and neutrophils are important non-invasive biomarkers for detecting the low-grade inflammatory status associated with this infection in pediatric patients. In terms of innate immunity, our findings emphasized that variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might express a more severe degree of inflammation. |
| Publish Date |
2021-08-05 14:37 |
| Citation |
Meliț LE, Mărginean CO, Săsăran MO, Mocan S, Ghiga DV, Bogliş A, Duicu C. Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis . World J Clin Cases 2021; 9(23): 6686-6697 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i23/6686.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i23.6686 |
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