Publication Name	World Journal of Gastroenterology
Manuscript ID	65987
Country	Greece

Received	2021-03-18 17:41
Peer-Review Started	2021-03-18 17:45
To Make the First Decision
Return for Revision	2021-07-03 05:36
Revised	2021-07-07 10:37
Second Decision	2021-10-13 06:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-10-14 02:57
Articles in Press	2021-10-14 02:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-07 20:03
Typeset the Manuscript	2021-10-29 08:40
Publish the Manuscript Online	2021-11-06 04:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Editorial
Article Title	Nucleic acid vaccines: A taboo broken and prospect for a hepatitis B virus cure
Manuscript Source	Invited Manuscript
All Author List	Efthymios P Tsounis, Athanasia Mouzaki and Christos Triantos
ORCID	Author(s) ORCID Number Efthymios P Tsounis http://orcid.org/0000-0003-2797-5070 Athanasia Mouzaki http://orcid.org/0000-0001-5548-7002 Christos Triantos http://orcid.org/0000-0003-3094-8209
Funding Agency and Grant Number
Corresponding Author	Christos Triantos, FAASLD, MD, PhD, Assistant Professor, Division of Gastroenterology, Department of Internal Medicine, University of Patras, D. Stamatopoulou 4, Patras 26504, Greece. chtriantos@hotmail.com
Key Words	Chronic hepatitis B; Therapeutic vaccination; Nucleic acid vaccines; DNA vaccines; Electroporation; Immunotherapy
Core Tip	A nucleic acid vaccine could be of particular value in the field of hepatitis B virus therapies. DNA vaccines have been studied more extensively over the past two decades and have been shown to overcome immune exhaustion in preclinical models of chronic infection. Although vaccination elicited robust humoral and cellular immune responses, it had negligible effects on clinical endpoints. Therefore, the scientific community has focused on optimizing vaccine design and delivery to improve immunogenicity. Electroporation-mediated delivery of multivalent plasmids in combination with molecular adjuvants could efficiently restore adaptive immunity in virally suppressed patients and be part of future combination therapy.
Publish Date	2021-11-06 04:43
Citation	Tsounis EP, Mouzaki A, Triantos C. Nucleic acid vaccines: A taboo broken and prospect for a hepatitis B virus cure. World J Gastroenterol 2021; 27(41): 7005-7013
URL	https://www.wjgnet.com/1007-9327/full/v27/i41/7005.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i41.7005

Full Article (PDF)	WJG-27-7005.pdf
Full Article (Word)	WJG-27-7005.docx
Manuscript File	65987_Auto_Edited-YJM-FilipodiaCL.docx
Answering Reviewers	65987-Answering reviewers.pdf
Audio Core Tip	65987-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65987-Conflict-of-interest statement.pdf
Copyright License Agreement	65987-Copyright license agreement.pdf
Peer-review Report	65987-Peer-review(s).pdf
Scientific Editor Work List	65987-Scientific editor work list.pdf
CrossCheck Report	65987-CrossCheck report.pdf