| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mitsuru Sugimoto, Kazumichi Abe, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takuto Hikichi and Hiromasa Ohira |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mitsuru Sugimoto, MD, PhD, Assistant Professor, Doctor, Department of Gastroenterology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. kitachuuou335@yahoo.co.jp |
| Key Words |
Pancreaticobiliary cancer; Diagnostic marker; Duodenal microbiota; Clostridium cluster XVIII; Cancer antigen 19-9 |
| Core Tip |
Recently, a correlation between the human microbiota and malignant gastrointestinal diseases was reported. In this report, the efficacy of the duodenal microbiota for diagnosing pancreaticobiliary cancer (PB Ca) was investigated. The combination of Clostridium cluster XVIII (cutoff value: 3.038%) and cancer antigen 19-9 Levels (cutoff value: 18.8 U/mL) showed 91.7% sensitivity and 71.4% specificity for diagnosing PB Ca. In conclusion, the duodenal microbiota may be useful for PB Ca screening. |
| Publish Date |
2021-12-14 23:58 |
| Citation |
Sugimoto M, Abe K, Takagi T, Suzuki R, Konno N, Asama H, Sato Y, Irie H, Watanabe K, Nakamura J, Kikuchi H, Takasumi M, Hashimoto M, Kato T, Kobashi R, Hikichi T, Ohira H. Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer. World J Gastrointest Oncol 2021; 13(12): 2088-2100 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i12/2088.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i12.2088 |
