| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Minireviews |
| Article Title |
Finding the seed of recurrence: Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Francesca Carissimi, Matteo Nazzareno Barbaglia, Livia Salmi, Cristina Ciulli, Linda Roccamatisi, Giuseppe Cordaro, Venkata Ramana Mallela, Rosalba Minisini, Biagio Eugenio Leone, Matteo Donadon, Guido Torzilli, Mario Pirisi, Fabrizio Romano and Simone Famularo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fabrizio Romano, MD, Professor, Surgeon, Surgical Oncologist, Department of Medicine and Surgery, University of Milan-Bicocca, via pergolesi 33, Monza 20900, Italy. fabrizio.romano@unimib.it |
| Key Words |
Hepatocellular carcinoma; Liquid biopsy; Circulating tumor cells; Liver surgery; Microvascular invasion; Hepatocellular carcinoma recurrence |
| Core Tip |
In recent years many studies have shown that surgery is the first choice treatment for hepatocellular carcinoma (HCC) patients; although undergoing surgery at early stage many patients develop relapse during follow-up. Currently, there are no tools sensitive enough to identify recurrence risk factors. Recent studies have identified liquid biopsy as a valid method for diagnosis, prognosis and treatment allocation in HCC patients thanks to its effectiveness in identification of circulating tumor cells (CTCs), advocated to be responsible for relapse. In this manuscript we describe the main markers expressed by CTCs and how their presence in blood sample may be implied in the progression mechanism, and how they can modify the surgical strategy. |
| Publish Date |
2021-09-18 13:32 |
| Citation |
Carissimi F, Barbaglia MN, Salmi L, Ciulli C, Roccamatisi L, Cordaro G, Mallela VR, Minisini R, Leone BE, Donadon M, Torzilli G, Pirisi M, Romano F, Famularo S. Finding the seed of recurrence: Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment. World J Gastrointest Surg 2021; 13(9): 967-978 |
| URL |
https://www.wjgnet.com/1948-9366/full/v13/i9/967.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v13.i9.967 |
