Publication Name	World Journal of Gastroenterology
Manuscript ID	6634
Country	China

Received	2013-10-26 09:25
Peer-Review Started	2013-10-26 12:36
First Decision by Editorial Office Director
Return for Revision	2013-12-04 16:39
Revised	2013-12-25 21:18
Publication Fee Transferred
Second Decision by Editor	2014-03-05 15:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-05 15:35
Articles in Press
Edit the Manuscript by Language Editor	2014-03-31 07:42
Typeset the Manuscript	2014-04-18 13:58
Publish the Manuscript Online	2014-05-07 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Naofen promotes TNF-α-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharide-treated rats
Manuscript Source	Invited Manuscript
All Author List	Jun-Hua Fan, Guo-Gang Feng, Lei Huang, Guo-Duo Tang, Hai-Xing Jiang and Jing Xu
Funding Agency and Grant Number
Corresponding Author	Jun-Hua Fan, MD, PhD, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. fanjunhuaxiaoshe@hotmail.com
Key Words	Naofen; Tumor necrosis factor-α; Apoptosis; Lipopolysaccharide; Kupffer cells; Caspase-3
Core Tip	Naofen, a WD40-repeat protein, is increased in the liver but not in the kidneys, thymus or spleen of rats injected with lipopolysaccharide (LPS). Increased naofen expression is blocked by pretreatment with anti-tumor necrosis factor (TNF)-α antibody. TNF-α has no effect on naofen expression or caspase-3 activation in primary hepatocytes, but conditioned medium from LPS-treated Kupffer cells (KC-CM) significantly enhances both. KC-CM-induced increase in naofen expression and caspase-3 activity is blocked by anti-TNF-α antibody. LPS in the liver may enhance release of TNF-α from KCs, and induce hepatocyte apoptosis, for which naofen promotes caspase-3 activity through the mitochondrial pathway.
Publish Date	2014-05-07 10:10
Citation	Fan JH, Feng GG, Huang L, Tang GD, Jiang HX, Xu J. Naofen promotes TNF-α-mediated apoptosis of hepatocytes by activating caspase-3 in lipopolysaccharide-treated rats. World J Gastroenterol 2014; 20(17): 4963-4971
URL	http://www.wjgnet.com/1007-9327/full/v20/i17/4963.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i17.4963

Full Article (PDF)	WJG-20-4963.pdf
Full Article (Word)	WJG-20-4963.doc
Manuscript File	6634-Review.docx
Answering Reviewers	6634-Answering reviewers.pdf
Copyright License Agreement	6634-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131025135224.jpg
Non-Native Speakers of English Editing Certificate	6634-Language certificate.PDF
Peer-review Report	6634-Peer review(s).pdf
Scientific Editor Work List	6634-Scientific editor work list.doc