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Articles Published Processes
10/21/2021 8:44:04 AM | Browse: 479 | Download: 952
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Received |
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2021-04-14 13:25 |
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Peer-Review Started |
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2021-04-14 13:27 |
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To Make the First Decision |
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Return for Revision |
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2021-06-12 21:52 |
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Revised |
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2021-06-27 22:51 |
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Second Decision |
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2021-09-13 02:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-16 23:00 |
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Articles in Press |
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2021-09-16 23:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-18 00:49 |
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Publish the Manuscript Online |
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2021-10-21 08:44 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Durim Delishaj, Ilaria Costanza Fumagalli, Stefano Ursino, Agostino Cristaudo, Francesco Colangelo, Antonio Stefanelli, Alessandro Alghisi, Giuseppe De Nobili, Romerai D'Amico, Alessandra Cocchi, Antonio Ardizzoia and Carlo Pietro Soatti |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Durim Delishaj, MD, Doctor, Doctor, Department of Radiation Oncology, Alessandro Manzoni Hospital, Via dell’Esremo, 9/11, Lecco 23900, Italy. d.delishaj@asst-lecco.it |
| Key Words |
Rectal cancer; Radiotherapy; Volumetric Modulated Arc Therapy; Image-guided radiotherapy; Intensity-modulated radiotherapy; Neoadjuvant radiotherapy |
| Core Tip |
We analyzed the role of neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers (LARC) using innovative radiotherapy techniques. A comprehensive literature search was performed on electronic database with a period limit from January 2009 to December 2020. According to PRISMA Group (2009) screening process only studies using equivalent dose 2 Gy fraction (EQD2) ≥ 54 Gy and Volumetric Modulated Arc Therapy, image-guided radiotherapy or image-guided radiotherapy techniques were included for the review. Neoadjuvant radiotherapy dose escalation using innovative techniques is safe for LARC with acceptable acute toxicity, achieving higher pathological complete response compared to standard treatment. EQD2 doses > 58.9 Gy with a BED > 70.7 Gy was associated with higher rate of surgical complications. |
| Publish Date |
2021-10-21 08:44 |
| Citation |
Delishaj D, Fumagalli IC, Ursino S, Cristaudo A, Colangelo F, Stefanelli A, Alghisi A, De Nobili G, D’Amico R, Cocchi A, Ardizzoia A, Soatti CP. Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature. World J Clin Cases 2021; 9(30): 9077-9089 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i30/9077.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i30.9077 |
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