Publication Name	World Journal of Clinical Cases
Manuscript ID	66475
Country	Italy

Received	2021-04-14 13:25
Peer-Review Started	2021-04-14 13:27
To Make the First Decision
Return for Revision	2021-06-12 21:52
Revised	2021-06-27 22:51
Second Decision	2021-09-13 02:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-16 23:00
Articles in Press	2021-09-16 23:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-18 00:49
Publish the Manuscript Online	2021-10-21 08:44

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature
Manuscript Source	Invited Manuscript
All Author List	Durim Delishaj, Ilaria Costanza Fumagalli, Stefano Ursino, Agostino Cristaudo, Francesco Colangelo, Antonio Stefanelli, Alessandro Alghisi, Giuseppe De Nobili, Romerai D'Amico, Alessandra Cocchi, Antonio Ardizzoia and Carlo Pietro Soatti
ORCID	Author(s) ORCID Number Durim Delishaj http://orcid.org/0000-0002-1782-0852 Ilaria Costanza Fumagalli http://orcid.org/0000-0001-5374-8029 Stefano Ursino http://orcid.org/0000-0003-3018-2338 Agostino Cristaudo http://orcid.org/0000-0002-9387-1109 Francesco Colangelo http://orcid.org/0000-0002-8843-4932 Antonio Stefanelli http://orcid.org/0000-0001-7415-1221 Alessandro Alghisi http://orcid.org/0000-0003-1244-2570 Giuseppe De Nobili http://orcid.org/0000-0001-7243-1609 Romerai D'Amico http://orcid.org/0000-0002-9003-9245 Alessandra Cocchi http://orcid.org/0000-0002-5936-1455 Antonio Ardizzoia http://orcid.org/0000-0003-2232-5677 Carlo Pietro Soatti http://orcid.org/0000-0002-0432-3494
Funding Agency and Grant Number
Corresponding Author	Durim Delishaj, MD, Doctor, Department of Radiation Oncology, Alessandro Manzoni Hospital, Via dell’Esremo, 9/11, Lecco 23900, Italy. d.delishaj@asst-lecco.it
Key Words	Rectal cancer; Radiotherapy; Volumetric Modulated Arc Therapy; Image-guided radiotherapy; Intensity-modulated radiotherapy; Neoadjuvant radiotherapy
Core Tip	We analyzed the role of neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers (LARC) using innovative radiotherapy techniques. A comprehensive literature search was performed on electronic database with a period limit from January 2009 to December 2020. According to PRISMA Group (2009) screening process only studies using equivalent dose 2 Gy fraction (EQD2) ≥ 54 Gy and Volumetric Modulated Arc Therapy, image-guided radiotherapy or image-guided radiotherapy techniques were included for the review. Neoadjuvant radiotherapy dose escalation using innovative techniques is safe for LARC with acceptable acute toxicity, achieving higher pathological complete response compared to standard treatment. EQD2 doses > 58.9 Gy with a BED > 70.7 Gy was associated with higher rate of surgical complications.
Publish Date	2021-10-21 08:44
Citation	Delishaj D, Fumagalli IC, Ursino S, Cristaudo A, Colangelo F, Stefanelli A, Alghisi A, De Nobili G, D’Amico R, Cocchi A, Ardizzoia A, Soatti CP. Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature. World J Clin Cases 2021; 9(30): 9077-9089
URL	https://www.wjgnet.com/2307-8960/full/v9/i30/9077.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i30.9077

Full Article (PDF)	WJCC-9-9077.pdf
Full Article (Word)	WJCC-9-9077.docx
Manuscript File	66475_Auto_Edited.docx
Answering Reviewers	66475-Answering reviewers.pdf
Audio Core Tip	66475-Audio core tip.mp3
Biostatistics Review Certificate	66475-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	66475-Conflict-of-interest statement.pdf
Copyright License Agreement	66475-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	66475-Language certificate.pdf
Peer-review Report	66475-Peer-review(s).pdf
Scientific Misconduct Check	66475-Bing-Wang LL-2.jpg
Scientific Editor Work List	66475-Scientific editor work list.pdf