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3/24/2022 2:13:21 PM | Browse: 291 | Download: 1000
Publication Name World Journal of Hepatology
Manuscript ID 66640
Country/Territory Ukraine
Received
2021-03-31 21:08
Peer-Review Started
2021-03-31 21:28
To Make the First Decision
Return for Revision
2021-07-27 02:22
Revised
2021-08-01 07:34
Second Decision
2022-02-21 07:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-02-23 21:03
Articles in Press
2022-02-23 21:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-03-18 05:02
Publish the Manuscript Online
2022-03-24 14:13
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Randomized Clinical Trial
Article Title Effect of a specific Escherichia coli Nissle 1917 strain on minimal/mild hepatic encephalopathy treatment
Manuscript Source Invited Manuscript
All Author List Elina Manzhalii, Valentyna Moyseyenko, Vitalii Kondratiuk, Nataliia Molochek, Tetyana Falalyeyeva and Nazarii Kobyliak
ORCID
Author(s) ORCID Number
Elina Manzhalii http://orcid.org/0000-0003-0920-4627
Valentyna Moyseyenko http://orcid.org/0000-0003-1402-6028
Vitalii Kondratiuk http://orcid.org/0000-0002-4891-2338
Nataliia Molochek http://orcid.org/0000-0001-6790-5099
Tetyana Falalyeyeva http://orcid.org/0000-0002-4415-9676
Nazarii Kobyliak http://orcid.org/0000-0001-9814-689X
Funding Agency and Grant Number
Corresponding Author Nazarii Kobyliak, PhD, Associate Professor, Department of Endocrinology, Bogomolets National Medical University, Pushkinska 22a str, Kyiv 01601, Ukraine. nazariikobyliak@gmail.com
Key Words Hepatic encephalopathy; Chronic liver disease; cirrhosis; Gut microbiota; E. coli Nissle 1917; Cognitive functions; Stroop test; Rifaximin; Lactulose
Core Tip In a prospective, single-centre, open-label, randomized study, the short-term efficacy and safety of Escherichia coli Nissle (EcN) 1917 compared to that of lactulose and rifaximin in patients with hepatic encephalopathy were evaluated. The probiotic reduced the ammonia content and the level of serum proinflammatory cytokines, normalized the gut microbiota composition and improved the cognitive functions of patients with hepatic encephalopathy. The application of the EcN strain was more effective than lactulose treatment.
Publish Date 2022-03-24 14:13
Citation Manzhalii E, Moyseyenko V, Kondratiuk V, Molochek N, Falalyeyeva T, Kobyliak N. Effect of a specific Escherichia coli Nissle 1917 strain on minimal/mild hepatic encephalopathy treatment. World J Hepatol 2022; 14(3): 634-646
URL https://www.wjgnet.com/1948-5182/full/v14/i3/634.htm
DOI https://dx.doi.org/10.4254/wjh.v14.i3.634
Full Article (PDF) WJH-14-634.pdf
Full Article (Word) WJH-14-634.docx
Manuscript File 66640_Auto_Edited.docx
Answering Reviewers 66640-Answering reviewers.pdf
Audio Core Tip 66640-Audio core tip.mp3
Biostatistics Review Certificate 66640-Biostatistics statement.pdf
Clinical Trial Registration Statement 66640-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 66640-Conflict-of-interest statement.pdf
Copyright License Agreement 66640-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 66640-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 66640-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 66640-Language certificate.pdf
Peer-review Report 66640-Peer-review(s).pdf
Scientific Misconduct Check 66640-Bing-Wang LL-2.png
Scientific Editor Work List 66640-Scientific editor work list.pdf