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Articles Published Processes
11/24/2021 9:54:22 AM | Browse: 385 | Download: 803
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Received |
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2021-04-03 10:56 |
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Peer-Review Started |
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2021-04-03 10:58 |
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To Make the First Decision |
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Return for Revision |
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2021-07-06 02:55 |
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Revised |
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2021-07-15 16:01 |
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Second Decision |
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2021-09-14 03:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-17 02:02 |
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Articles in Press |
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2021-09-17 02:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-18 03:30 |
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Publish the Manuscript Online |
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2021-11-24 09:54 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of immune dysfunction in drug induced liver injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chandrashekaran Girish and Sukumaran Sanjay |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chandrashekaran Girish, MSc, PhD, Additional Professor, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, NA, Puducherry 605006, India. gcnx2005@gmail.com |
| Key Words |
Immune dysfunction; Liver damage; Hepatotoxic drugs; Drug-induced liver injury; High mobility group box 1 |
| Core Tip |
This review demonstrates the critical role of the immune system in the progression of drug-induced liver injury and also in determining the severity of the damage. Drugs affect the normal functioning of hepatocytes through several direct and indirect mechanisms leading to the dysfunctional immune response. The major effector cells in amplifying liver damage are Kupffer cells, monocytes and neutrophils. Genetic predispositions and environmental factors also make individuals vulnerable to immune dysfunction. |
| Publish Date |
2021-11-24 09:54 |
| Citation |
Girish C, Sanjay S. Role of immune dysfunction in drug induced liver injury. World J Hepatol 2021; 13(11): 1677-1687 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i11/1677.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i11.1677 |
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