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Articles Published Processes
9/29/2021 11:12:00 AM | Browse: 726 | Download: 2040
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Received |
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2021-04-08 11:05 |
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Peer-Review Started |
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2021-04-08 11:08 |
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First Decision by Editorial Office Director |
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2021-06-26 03:31 |
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Return for Revision |
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2021-06-26 03:31 |
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Revised |
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2021-07-06 02:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-09-01 02:13 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-09-01 09:32 |
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Articles in Press |
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2021-09-01 09:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-09-27 01:24 |
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Publish the Manuscript Online |
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2021-09-29 11:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ai-Ru Hsieh, Cathy S J Fann, Hung-Chun Lin, Jennifer Tai, Sen-Yung Hsieh and Dar-In Tai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chang Gung Memorial Hospital |
CMRPG3C0701 |
| National Science Council |
NSC101-2314-B-182A-025-MY3 |
| National Science Council |
MOST 107-2314-B-039-059 |
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| Corresponding Author |
Dar-In Tai, MD, PhD, Professor, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, No. 5 Fuxing Street, Guishan District, Taoyuan 33305, Taiwan. tai48978@cgmh.org.tw |
| Key Words |
Generalized estimating equation; Genetic polymorphism; Genome-wide association study; Hepatitis B surface antigen; Hepatitis B virus; Replication |
| Core Tip |
Hepatitis B virus (HBV)-related single nucleotide polymorphisms (SNPs) have been identified in East Asians. We evaluated five SNPs and nongenetic factors associated with HBV infection in a hepatocellular carcinoma family cohort. The factors were correlated with hepatitis B surface antigen (HBsAg) in the first-stage and with HBV viral load in the second-stage. The SNPs, sex, generation, and index case HBsAg contributed to persistent HBV infection. Neonatal tolerance and SNPs in the HLA loci were both independently associated with persistent HBV infection. A prolonged HBV replication phase in parents could be the main mechanism of persistent HBV infection in children in East Asia. |
| Publish Date |
2021-09-29 11:12 |
| Citation |
Hsieh AR, Fann CSJ, Lin HC, Tai J, Hsieh SY, Tai DI. Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families. World J Gastroenterol 2021; 27(37): 6262-6276 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i37/6262.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i37.6262 |
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