Publication Name	World Journal of Gastroenterology
Manuscript ID	66939
Country	United Kingdom

Received	2021-04-09 20:10
Peer-Review Started	2021-04-09 20:12
To Make the First Decision	2021-05-17 07:39
Return for Revision	2021-05-17 07:40
Revised	2021-05-18 20:14
Second Decision	2021-11-25 05:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-28 07:17
Articles in Press	2021-11-28 07:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-07 02:47
Publish the Manuscript Online	2021-12-10 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	T cells in pancreatic cancer stroma
Manuscript Source	Invited Manuscript
All Author List	Michelle R Goulart, Konstantinos Stasinos, Rachel Elizabeth Ann Fincham, Francesca R Delvecchio and Hemant M Kocher
ORCID	Author(s) ORCID Number Michelle R Goulart http://orcid.org/0000-0001-8333-3908 Konstantinos Stasinos http://orcid.org/0000-0002-5670-3034 Rachel Elizabeth Ann Fincham http://orcid.org/0000-0002-4699-5002 Francesca R Delvecchio http://orcid.org/0000-0002-3661-1212 Hemant M Kocher http://orcid.org/0000-0001-6771-1905
Funding Agency and Grant Number
Corresponding Author	Hemant M Kocher, FRCS (Gen Surg), MBBS, MD, MS, Professor, Centre for Tumour Biology Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom. h.kocher@qmul.ac.uk
Key Words	Immunosuppression; T cell exhaustion; Tumour microenvironment; Pancreatic ductal adenocarcinoma; Pancreatic cancer stroma
Core Tip	Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with a dismal 5-year survival of less than 5% in patients with metastatic disease, and is predicted to become the second cause of cancer-related death by 2030. Here, we discuss the complexity of the PDAC immunosuppressive tumour microenvironment, the mechanisms involved in T cell dysfunction, and potential immunotherapeutic strategies for treating PDAC.
Publish Date	2021-12-10 09:08
Citation	Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM. T cells in pancreatic cancer stroma. World J Gastroenterol 2021; 27(46): 7956-7968
URL	https://www.wjgnet.com/1007-9327/full/v27/i46/7956.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i46.7956

Full Article (PDF)	WJG-27-7956.pdf
Full Article (Word)	WJG-27-7956.docx
Manuscript File	66939_Auto_Edited.docx
Answering Reviewers	66939-Answering reviewers.pdf
Audio Core Tip	66939-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	66939-Conflict-of-interest statement.pdf
Copyright License Agreement	66939-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	66939-Grant application form(s).pdf
Peer-review Report	66939-Peer-review(s).pdf
Scientific Misconduct Check	66939-Bing-Gao CC-2.png
Scientific Editor Work List	66939-Scientific editor work list.pdf
CrossCheck Report	66939-CrossCheck report.pdf