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Articles Published Processes
10/13/2021 8:37:10 AM | Browse: 411 | Download: 1352
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Received |
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2021-04-14 20:08 |
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Peer-Review Started |
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2021-04-14 20:11 |
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To Make the First Decision |
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Return for Revision |
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2021-05-12 05:38 |
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Revised |
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2021-06-07 22:26 |
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Second Decision |
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2021-09-06 03:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-06 10:58 |
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Articles in Press |
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2021-09-06 10:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-09-26 00:54 |
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Publish the Manuscript Online |
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2021-10-13 08:37 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qiong Wei, Jong Han Lee, Chia-Shan Wu, Qun S Zang, Shaodong Guo, Hui-Chen Lu and Yuxiang Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
DK118334 |
| NIH |
AG064869 |
| BrightFocus |
A2019630S |
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| Corresponding Author |
Yuxiang Sun, MD, PhD, Associate Professor, Department of Nutrition, Texas A and M University, 214C Cater-Mattil; 2253 TAMU College Station, TX 77843-2253 Phone: 979-862-9143 (office); 979-862-9144 (lab). Fax: 979-458-3129, College Station TX, 7743, United States. yuxiangs@tamu.edu |
| Key Words |
Cannabinoid type 1 receptor; Adiponectin; Thermogenesis; Macrophages; Inflammation; Insulin resistance |
| Core Tip |
Antagonists of cannabinoid type 1 receptor (CB1) have been shown to promote body weight loss and improve insulin sensitivity. Cannabinoids have been shown to regulate adiponectin. However, it is unclear whether adiponectin is a key mediator of the functions of CB1. We compared metabolic and inflammatory phenotypes of CB1-null vs CB1/adiponectin double-knockout mice. Our findings reveal that CB1 functions through both adiponectin-dependent and adiponectin-independent mechanisms: CB1 regulates energy metabolism in an adiponectin-independent manner, and inflammation in an adiponectin-dependent manner. |
| Publish Date |
2021-10-13 08:37 |
| Citation |
Wei Q, Lee JH, Wu CS, Zang QS, Guo SD, Lu HC, Sun YX. Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin. World J Diabetes 2021; 12(10): 1750-1764 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i10/1750.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i10.1750 |
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