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Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 366 | Download: 690
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Received |
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2021-04-14 05:27 |
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Peer-Review Started |
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2021-04-20 08:37 |
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To Make the First Decision |
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Return for Revision |
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2021-06-24 05:40 |
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Revised |
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2021-06-24 14:34 |
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Second Decision |
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2021-08-23 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-23 07:32 |
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Articles in Press |
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2021-08-23 07:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-05 11:24 |
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Typeset the Manuscript |
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2021-11-09 09:43 |
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Publish the Manuscript Online |
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2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Genome-wide CRISPR-Cas9 screening identifies hypoxia-inducible factor-1a-meditated CBX8 promotes pancreatic cancer progression via IRS1/AKT axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bu-Wei Teng, Kun-Dong Zhang, Yu-Han Yang, Zeng-Ya Guo, Wei-Wei Chen and Zheng-Jun Qiu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81974372 (to Qiu ZJ) |
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| Corresponding Author |
Zheng-Jun Qiu, MD, Chief Doctor, Director, Director, Surgeon, Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Shanghai 201600, China. qiuzjdoctor@sina.com |
| Key Words |
CRISPR-Cas9 screening; Pancreatic cancer; Chromobox 8; Hypoxia; pI3K/AKT signaling |
| Core Tip |
The authors demonstrated that hypoxia-inducible factor-1a induced chromobox (CBX)8 transcription by combining with the promoter of CBX8. CBX8 efficiently activated the PI3K/AKT signaling by upregulating insulin receptor substrate 1. The newly identified signaling axis may support the development of new therapeutic strategies for pancreatic cancer. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Teng BW, Zhang KD, Yang YH, Guo ZY, Chen WW, Qiu ZJ. Genome-wide CRISPR-Cas9 screening identifies that hypoxia-inducible factor-1a-induced CBX8 transcription promotes pancreatic cancer progression via IRS1/AKT axis. World J Gastrointest Oncol 2021; 13(11): 1709-1724 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1709.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1709 |
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