BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 602 | Download: 1360
 |
Received |
|
2021-04-14 05:27 |
|
Peer-Review Started |
|
2021-04-20 08:37 |
|
First Decision by Editorial Office Director |
|
2021-06-23 22:19 |
|
Return for Revision |
|
2021-06-24 05:40 |
|
Revised |
|
2021-06-24 14:34 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2021-08-23 02:39 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2021-08-23 07:32 |
|
Articles in Press |
|
2021-08-23 07:32 |
|
Edit the Manuscript by Language Editor |
|
2021-09-05 11:24 |
|
Typeset the Manuscript |
|
2021-11-09 09:43 |
|
Publish the Manuscript Online |
|
2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Genome-wide CRISPR-Cas9 screening identifies hypoxia-inducible factor-1a-meditated CBX8 promotes pancreatic cancer progression via IRS1/AKT axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bu-Wei Teng, Kun-Dong Zhang, Yu-Han Yang, Zeng-Ya Guo, Wei-Wei Chen and Zheng-Jun Qiu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81974372 (to Qiu ZJ) |
|
| Corresponding Author |
Zheng-Jun Qiu, MD, Chief Doctor, Director, Director, Surgeon, Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Shanghai 201600, China. qiuzjdoctor@sina.com |
| Key Words |
CRISPR-Cas9 screening; Pancreatic cancer; Chromobox 8; Hypoxia; pI3K/AKT signaling |
| Core Tip |
The authors demonstrated that hypoxia-inducible factor-1a induced chromobox (CBX)8 transcription by combining with the promoter of CBX8. CBX8 efficiently activated the PI3K/AKT signaling by upregulating insulin receptor substrate 1. The newly identified signaling axis may support the development of new therapeutic strategies for pancreatic cancer. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Teng BW, Zhang KD, Yang YH, Guo ZY, Chen WW, Qiu ZJ. Genome-wide CRISPR-Cas9 screening identifies that hypoxia-inducible factor-1a-induced CBX8 transcription promotes pancreatic cancer progression via IRS1/AKT axis. World J Gastrointest Oncol 2021; 13(11): 1709-1724 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1709.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1709 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
