Publication Name	World Journal of Gastroenterology
Manuscript ID	6715
Country	Japan

Received	2013-10-27 21:17
Peer-Review Started	2013-10-28 11:37
To Make the First Decision	2013-12-16 17:48
Return for Revision	2013-12-17 16:39
Revised	2013-12-19 16:30
Second Decision	2014-05-05 08:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-05 09:48
Articles in Press	2014-05-23 10:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-18 09:13
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids
Manuscript Source	Invited Manuscript
All Author List	Ikuo Nakamura
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Culture, Sports, Science and Technology of Japan Ministry of Health, Labor and Welfare of Japan
Corresponding Author	Ikuo Nakamura, MD, PhD, Department of Gastroenterology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. ikuonaka@tokyo-med.ac.jp
Key Words	Branched-chain amino acids; Liver cirrhosis; Innate immunity; Natural killer cell activity of lymphocytes; Phagocytic function of neutrophils
Core Tip	This review will discuss the recent research on impairment of innate immune responses in cirrhotic patients and the treatment by branched-chain amino acids (BCAA). It was revealed that BCAA oral supplementation could improve not only nutrition status but phagocytic function of neutrophils and natural killer activity of lymphocytes in cirrhotic patients. Therefore, BCAA supplementation might reduce the risk of bacterial and viral infection in patients with decompensated cirrhosis. Additionally, it was also revealed that BCAA oral supplementation could reduce the risk of development of hepatocellular carcinoma in cirrhotic patients. The mechanisms of the effects of BCAA described above will also be discussed.
Publish Date	2014-06-21 13:56
Citation	Nakamura I. Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids. World J Gastroenterol 2014; 20(23): 7298-7305
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7298.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7298

Full Article (PDF)	WJG-20-7298.pdf
Full Article (Word)	WJG-20-7298.doc
Manuscript File	6715-Review.docx
Answering Reviewers	6715-Answering reviewers.pdf
Copyright License Agreement	6715-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131027152057.doc
Peer-review Report	6715-Peer review(s).pdf
Scientific Editor Work List	6715-Scientific editor work list.pdf