Publication Name	World Journal of Stem Cells
Manuscript ID	67215
Country	Pakistan

Received	2021-04-18 13:10
Peer-Review Started	2021-04-18 13:14
To Make the First Decision
Return for Revision	2021-07-18 03:05
Revised	2021-07-31 19:33
Second Decision	2021-12-09 03:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-10 03:08
Articles in Press	2021-12-10 03:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-13 09:13
Publish the Manuscript Online	2021-12-25 08:37

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Strategies to improve regenerative potential of mesenchymal stem cells
Manuscript Source	Invited Manuscript
All Author List	Mahmood S Choudhery
ORCID	Author(s) ORCID Number Mahmood S Choudhery http://orcid.org/0000-0003-2038-4817
Funding Agency and Grant Number
Corresponding Author	Mahmood S Choudhery, PhD, Associate Professor, Department of Genetics and Molecular Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore 54600, Punjab, Pakistan. ms20031@yahoo.com
Key Words	Hypoxia; Stem cell aging; Growth factors; Heat shock; Caloric restriction
Core Tip	Stem cell-based therapies can treat various diseases and disorders. Mesenchymal stem cells have high self-renewal as well as differentiation potential, however; their potential for cell-based therapies is severely compromised with donor age, disease status and extensive in vitro expansion. Thus autologous use of stem cells isolated from unhealthy, older donors does not seem to give optimal results. It is therefore essential to improve the negative age and disease effects on resident adult stem cells before clinical use. We herein discuss the strategies such as hypoxia, heat shock, caloric restriction and preconditioning with different factors to enhance the stem cell function.
Publish Date	2021-12-25 08:37
Citation	Choudhery MS. Strategies to improve regenerative potential of mesenchymal stem cells. World J Stem Cells 2021; 13(12): 1845-1862
URL	https://www.wjgnet.com/1948-0210/full/v13/i12/1845.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i12.1845

Full Article (PDF)	WJSC-13-1845.pdf
Full Article (Word)	WJSC-13-1845.docx
Manuscript File	67215_Auto_Edited .docx
Answering Reviewers	67215-Answering reviewers.pdf
Audio Core Tip	67215-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67215-Conflict-of-interest statement.pdf
Copyright License Agreement	67215-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67215-Language certificate.pdf
Peer-review Report	67215-Peer-review(s).pdf
Scientific Misconduct Check	67215-Bing-Fan JR-2.png
Scientific Editor Work List	67215-Scientific editor work list.pdf
CrossCheck Report	67215-CrossCheck report.pdf
CrossCheck Report	67215-CrossCheck.png