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12/27/2021 5:24:00 AM | Browse: 696 | Download: 1315
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Received |
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2021-04-22 22:49 |
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Peer-Review Started |
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2021-04-22 22:51 |
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First Decision by Editorial Office Director |
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2021-06-15 21:59 |
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Return for Revision |
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2021-06-15 21:59 |
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Revised |
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2021-07-09 13:24 |
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2021-11-16 03:29 |
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Final Decision by Editorial Office Director |
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2021-11-18 06:43 |
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Articles in Press |
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2021-11-18 06:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-13 08:53 |
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Publish the Manuscript Online |
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2021-12-27 05:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gergana Taneva, Dimitar Dimitrov and Tsvetelina Velikova |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tsvetelina Velikova, MD, PhD, Assistant Professor, Department of Clinical Immunology, University Hospital Lozenetz, Kozyak 1 Str., Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg |
| Key Words |
Liver dysfunction; Liver damage; Cytokine storm; Prognostic factor; COVID-19; Severe COVID-19; SARS-CoV-2; Aspartate aminotransferase; Alanine aminotransferase; Bilirubin; Interleukin-6 |
| Core Tip |
Looking at the liver tests in patients with severe coronavirus disease 2019 (COVID-19), C-reactive protein (CRP) showed a strong correlation with the aspartate aminotransferase (AST) levels. This was observed in both intensive care units (ICU) and non-ICU patients. However, CRP levels were higher in non-ICU patients with liver damage, whereas alanine aminotransferase (ALT) was higher in ICU COVID-19 patients. Thus, like interleukin-6 (IL-6), ferritin, and CRP correlated directly with AST and ALT levels in non-ICU patients, there is a direct correlation of IL-6 and acute phase proteins with AST in severe COVID-19 cases. These observations confirm the critical impact of systemic inflammation and specifically elevated IL-6 during severe acute respiratory coronavirus 2 cytokine storm on liver injury. |
| Publish Date |
2021-12-27 05:24 |
| Citation |
Taneva G, Dimitrov D, Velikova T. Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19. World J Hepatol 2021; 13(12): 2005-2012 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i12/2005.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i12.2005 |
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