| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ekaterina Kuligina, Fedor Moiseyenko, Sergey Belukhin, Ekaterina Stepanova, Maria Zakharova, Vera Chernobrivtseva, Ikram Aliev, Tatiana Sharabura, Vladimir Moiseyenko, Svetlana Aleksakhina, Tatiana Laidus, Aleksandr Martianov, Maksim Kholmatov, Aldon Whitehead, Grigoriy Yanus and Evgeny Imyanitov |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Russian Science Foundation |
20-75-10163 |
|
| Corresponding Author |
Evgeny Imyanitov, DSc, Professor, Department of Tumor Biology, N.N. Petrov Institute of Oncology, Pesochny, St.-Petersburg 19775, Russia. evgeny@imyanitov.spb.ru |
| Key Words |
Liquid biopsy; Rectal cancer; KRAS; BRAF; Mutations; Tumor response; Radiotherapy |
| Core Tip |
The detection of circulating tumor DNA (ctDNA) in cancer patients is compromised by the low sensitivity of this assay. We hypothesized that tumor irradiation may lead to the transient increase of ctDNA content due to induction of cell death. Nine patients with locally advanced RAS/RAF-mutated rectal cancer provided serial blood samples at baseline and during the first 96 h after the first dose of tumor irradiation. Treatment-induced elevation of the concentration of mutated RAS/RAF alleles in the blood was revealed in five of these subjects. In conclusion, local tumor irradiation may facilitate the detection of plasma ctDNA and thus improve the efficacy of liquid biopsy. |
| Publish Date |
2021-12-24 09:38 |
| Citation |
Kuligina E, Moiseyenko F, Belukhin S, Stepanova E, Zakharova M, Chernobrivtseva V, Aliev I, Sharabura T, Moiseyenko V, Aleksakhina S, Laidus T, Martianov A, Kholmatov M, Whitehead A, Yanus G, Imyanitov E. Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma. World J Clin Oncol 2021; 12(12): 1215-1226 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i12/1215.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i12.1215 |
