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Articles Published Processes
4/30/2022 5:08:22 AM | Browse: 335 | Download: 835
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Received |
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2021-04-24 09:55 |
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Peer-Review Started |
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2021-04-24 09:59 |
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To Make the First Decision |
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Return for Revision |
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2021-06-14 06:25 |
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Revised |
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2021-06-25 14:01 |
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Second Decision |
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2022-03-28 05:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-04-04 05:22 |
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Articles in Press |
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2022-04-04 05:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-03-21 21:30 |
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Typeset the Manuscript |
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2022-04-19 02:17 |
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Publish the Manuscript Online |
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2022-04-30 05:08 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zoltan Herold, Magdolna Herold, Gyorgy Herczeg, Agnes Fodor, Attila Marcell Szasz, Magdolna Dank and Aniko Somogyi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund |
UNKP-20-4-I |
| National Research, Development and Innovation Office |
K-116128 |
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| Corresponding Author |
Zoltan Herold, MSc, PhD, Research Scientist, Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 25-29 Tomo u, Budapest H-1083, Hungary. herold.zoltan@med.semmelweis-univ.hu |
| Key Words |
CD40 ligand; Colorectal neoplasms; Interleukin-6; Thrombocytosis; Thrombopoietin |
| Core Tip |
This observational study investigated whether plasma CD40 ligand (CD40L) is related to colorectal cancer (CRC)-associated thrombocytosis and disease severity. Baseline CD40L was significantly higher in patients with distant metastasis and thrombocytosis. An association between CD40L, platelet count, and the interleukin-6 level was found. CD40L was constant with the course of the disease, and all its baseline differences persisted throughout the study. Both pre- and postoperative high CD40L levels negatively affected overall, disease-specific, and thrombocytosis-eliminated survival. A possible connection between elevated CD40L levels and increased general inflammation caused by CRC was also suggested. |
| Publish Date |
2022-04-30 05:08 |
| Citation |
Herold Z, Herold M, Herczeg G, Fodor A, Szasz AM, Dank M, Somogyi A. High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer. World J Clin Cases 2022; 10(13): 4084-4096 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i13/4084.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i13.4084 |
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