| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Survival effect of probiotics in a rat model of colorectal cancer treated with capecitabine
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Graciela Gigola, Pedro Carriere, María Belén Novoa Díaz, Gabriela Perdigon, Ariel Osvaldo Zwenger and Claudia Gentili |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Universidad Nacional del Sur, Argentina |
GI 24/B138 |
| Universidad Nacional del Sur, Argentina |
PGI 24/ZB50 |
| Universidad Nacional del Sur, Argentina |
PGI 24/ZB63 |
|
| Corresponding Author |
Graciela Gigola, PhD, Doctor, Doctor, Professor, Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Buenos Aires Provincia, Argentina. ggigola@uns.edu.ar |
| Key Words |
Colorectal cancer; Capecitabine; Probiotics; Survival; Life quality; Animal experimentation |
| Core Tip |
Today it is still unclear which are the most effective forms of probiotics administration at long-term to reduce the incidence of human colorectal cancer (CRC) or which microorganisms are the most suitable; the amount, time and frequency that should be consumed in the diet. Also, which is their influence on side effect from chemotherapy in CRC? Herein we show, for the first time, that probiotics have a positive impact on the overall survival of rats with CRC under capecitabine treatment. These animals have also a benefit in weight gain, clinical manifestations, developing cancer, number, localization and tumor burden. |
| Publish Date |
2021-10-13 12:57 |
| Citation |
Gigola G, Carriere P, Novoa Díaz MB, Perdigon G, Zwenger AO, Gentili C. Survival effect of probiotics in a rat model of colorectal cancer treated with capecitabine. World J Gastrointest Oncol 2021; 13(10): 1518-1531 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i10/1518.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i10.1518 |
