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Articles Published Processes
10/26/2021 3:59:25 AM | Browse: 515 | Download: 1222
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Received |
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2021-04-26 16:27 |
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Peer-Review Started |
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2021-04-26 16:31 |
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To Make the First Decision |
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Return for Revision |
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2021-05-12 01:52 |
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Revised |
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2021-06-14 17:00 |
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Second Decision |
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2021-08-23 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-23 07:45 |
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Articles in Press |
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2021-08-23 07:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-03 20:20 |
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Typeset the Manuscript |
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2021-10-22 07:35 |
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Publish the Manuscript Online |
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2021-10-26 03:59 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Impact of senescence on the trans-differentiation process of human hepatic progenitor-like cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Francesco Bellanti, Giorgia di Bello, Rosanna Tamborra, Marco Amatruda, Aurelio Lo Buglio, Michał Dobrakowski, Aleksandra Kasperczyk, Sławomir Kasperczyk, Gaetano Serviddio and Gianluigi Vendemiale |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Francesco Bellanti, MD, PhD, Doctor, Doctor, Research Associate, Teaching Assistant, Department of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, Foggia 71122, Italy. francesco.bellanti@unifg.it |
| Key Words |
Senescence; HepaRG cells; Trans-differentiation; Mitochondria; Regeneration; Nicotinamide adenine dinucleotide |
| Core Tip |
The human HepaRG cell line represents an effective model for the study of liver metabolism and hepatic progenitors. However, the impact of senescence on HepaRG cells is not known. We characterized the effects of senescence on the trans-differentiation capacity and mitochondrial metabolism of HepaRG cells. By using a replication protocol, we described higher senescence-associated markers and lower trans-differentiation markers in passage 20 (P20) than passage 10 (P10) cells. Cellular and mitochondrial oxygen consumption, ATP and NAD+/NADH content were lower in P20 than P10 trans-differentiated cells. To conclude, senescence-associated mitochondrial dysfunction may limit the trans-differentiation potential of HepaRG cells. |
| Publish Date |
2021-10-26 03:59 |
| Citation |
Bellanti F, di Bello G, Tamborra R, Amatruda M, Lo Buglio A, Dobrakowski M, Kasperczyk A, Kasperczyk S, Serviddio G, Vendemiale G. Impact of senescence on the trans-differentiation process of human hepatic progenitor-like cells. World J Stem Cells 2021; 13(10): 1595-1609 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i10/1595.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i10.1595 |
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