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Articles Published Processes
11/6/2021 4:43:07 AM | Browse: 386 | Download: 795
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Received |
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2021-04-27 19:54 |
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Peer-Review Started |
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2021-04-27 19:56 |
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To Make the First Decision |
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Return for Revision |
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2021-06-13 02:21 |
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Revised |
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2021-06-26 14:12 |
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Second Decision |
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2021-08-23 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-23 05:59 |
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Articles in Press |
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2021-08-23 05:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-10-09 03:35 |
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Typeset the Manuscript |
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2021-10-29 08:41 |
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Publish the Manuscript Online |
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2021-11-06 04:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Frontier |
| Article Title |
Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
María Belén Novoa Díaz, Pedro Matías Carriere, María Julia Martín, Natalia Calvo and Claudia Gentili |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Agencia Nacional de Promoción Científica y Tecnológica |
PICT-2013-1441 |
| Consejo Nacional de Investigaciones Científicas y Técnicas |
PIP11220150100350 |
| Instituto Nacional del Cáncer (Asistencia financiera II) |
12002-4395-14-1 |
| Instituto Nacional del Cáncer (Asistencia financiera III) |
RESOL-2016-1006-E-APN-MS |
| Universidad Nacional del Sur |
PGI: 24/B230; PGI: 24/B303 |
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| Corresponding Author |
Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar |
| Key Words |
Parathyroid hormone-related protein; Colorectal cancer; Tumor biomarkers; Neoplastic processes; Drug resistance; Tumor microenvironment |
| Core Tip |
In colorectal cancer (CRC) cells, we found that parathyroid hormone-related peptide (PTHrP) promotes survival, cell cycle progression, proliferation, migration, chemoresistance and also modulates markers expression associated with invasion, angiogenesis, epithelial to mesenchymal transition and cancer stem cells features. In vivo tests indicate that PTHrP administration increases the expression of several markers related to tumorigenic events. Recently we observed that PTHrP influences on tumor microenvironment cells inducing events associated with the progression of CRC. Our project focuses in understanding the biology of CRC and the underlying mechanisms related to the aggressive behavior of CRC cells with the aim to identify new markers that improve the diagnosis, prognosis and therapy of CRC. |
| Publish Date |
2021-11-06 04:43 |
| Citation |
Novoa Díaz MB, Carriere PM, Martín MJ, Calvo N, Gentili C. Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells. World J Gastroenterol 2021; 27(41): 7025-7040 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i41/7025.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i41.7025 |
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