| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bi-specific T1 positive-contrast-enhanced magnetic resonance imaging molecular probe for hepatocellular carcinoma in an orthotopic mouse model
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Hong Ma, Kun Chen, Shuang Wang, Si-Yun Liu, Deng-Feng Li, Yong-Tao Mi, Zhi-Yuan Wu, Chun-Feng Qu and Xin-Ming Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| PUMC Youth Fund |
2017320010 |
| Chinese Academy of Medical Sciences (CAMS) Research Fund |
ZZ2016B01 |
| Beijing HopeRun Special Fund of Cancer Foundation of China |
LC2016B15 |
|
| Corresponding Author |
Xin-Ming Zhao, MD, Chairman, Professor, Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. zhaoxinming@cicams.ac.cn |
| Key Words |
Hepatocellular carcinoma; Molecular imaging; Magnetic resonance imaging; Positive contrast agent; Alpha-fetoprotein; Glypican-3 |
| Core Tip |
Use of single biomarkers might hinder the detection efficiency of existing hepatocellular carcinoma (HCC) molecular probes due to tumor heterogeneity, while negative (T2) contrast agents could result in inaccurate diagnoses. Therefore, we developed double-antigen-targeting magnetic resonance imaging (MRI) probes for hepatic tumors by conjugating alpha-fetoprotein or glypican-3 antibodies simultaneously to a 5-nm ultra-small superparamagnetic iron oxide (USPIO) and investigated its performance in orthotopic HCC mouse model. The bi-specific T1-positive contrast-enhanced MRI probe for HCC demonstrated increased specificity and sensitivity to diagnose early-stage HCC irrespective of tumor size and/or heterogeneity. Moreover, the in vivo enhancement of imaging by the USPIO probes appeared dose-dependent and requires further investigation. |
| Publish Date |
2022-04-15 09:40 |
| Citation |
Ma XH, Chen K, Wang S, Liu SY, Li DF, Mi YT, Wu ZY, Qu CF, Zhao XM. Bi-specific T1 positive-contrast-enhanced magnetic resonance imaging molecular probe for hepatocellular carcinoma in an orthotopic mouse model. World J Gastrointest Oncol 2022; 14(4): 858-871 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i4/858.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i4.858 |
