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Articles Published Processes
1/11/2022 8:34:26 AM | Browse: 449 | Download: 1402
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Received |
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2021-04-29 01:02 |
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Peer-Review Started |
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2021-04-29 01:04 |
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To Make the First Decision |
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Return for Revision |
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2021-06-17 02:28 |
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Revised |
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2021-07-13 07:05 |
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Second Decision |
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2021-12-31 03:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-31 21:58 |
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Articles in Press |
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2021-12-31 21:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-12-13 22:21 |
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Typeset the Manuscript |
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2022-01-05 07:27 |
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Publish the Manuscript Online |
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2022-01-11 08:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Observational Study |
| Article Title |
Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abeer Babiker Idris, Alaa B Idris, Manal A Gumaa, Mohammed Babiker Idris, Amanda Elgoraish, Mohamed Mansour, Dalia Allam, Bashir MO Arbab, Nazar Beirag, El-Amin M Ibrahim and Mohamed A Hassan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abeer Babiker Idris, DSc, Academic Research, Department of Agricultural Science and Technology, Institute of Natural and Applied Sciences, Erciyes University, Merkez Kampüs Talas Yolu Melikgazi, Kayseri 38039, Türkiye. abeer.babiker89@gmail.com |
| Key Words |
5’-region; Promoter; TNF-A; Helicobacter pylori; In silico analysis; Sudan |
| Core Tip |
According to the literature, a considerable number of polymorphisms have been discovered in the tumor necrosis factor-alpha (TNF-A) promoter. A crucial question is whether these polymorphisms have any significant functional impact on disease incidence or severity. Seven single nucleotide polymorphisms were detected in the TNF-A 5’-region; only one of them, TNF-A-76, was located at the in silico-predicted promoter region (-146 to +10). This single nucleotide polymorphism may lead to the modification of the transcriptional regulation of TNF-A in Helicobacter pylori infection. Nevertheless, this conclusion cannot substitute for the experimental proofs, but it can provide direction or insight for them. |
| Publish Date |
2022-01-11 08:34 |
| Citation |
Idris AB, Idris AB, Gumaa MA, Idris MB, Elgoraish A, Mansour M, Allam D, Arbab BM, Beirag N, Ibrahim EAM, Hassan MA. Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach. World J Gastroenterol 2022; 28(2): 242-262 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i2/242.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i2.242 |
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