Publication Name	World Journal of Gastroenterology
Manuscript ID	6771
Country	Serbia

Received	2013-10-29 08:46
Peer-Review Started	2013-10-29 21:09
To Make the First Decision	2013-12-16 17:43
Return for Revision	2013-12-18 14:40
Revised	2014-01-05 03:36
Second Decision	2014-03-05 14:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-05 15:10
Articles in Press	2014-05-23 11:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-27 10:09
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Clinical implications of hepatitis B virus mutations: Recent advances
Manuscript Source	Invited Manuscript
All Author List	Ivana Lazarevic
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Science and Technological Development, Republic of Serbia 175073
Corresponding Author	Ivana Lazarevic, MD, PhD, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia. ilazarevic@med.bg.ac.rs
Key Words	Hepatitis B virus; Hepatitis B virus variability; Mutation; Drug resistance; Vaccine escape
Core Tip	Understanding the frequencies and clinical implications of Hepatitis B virus (HBV) mutations may contribute to improvement of diagnostic procedures, more proper planning of immunization programs and creating the most efficient therapeutic protocols. This paper brings an overview and latest research results on the most important, clinically relevant, HBV mutations. The covered topics include mutations involved in vaccine-escape phenomenon, resistance to currently available antiviral drugs, development of “occult” hepatitis, hepatocellular carcinoma, fulminant hepatitis and hepatitis B e antigen-negative hepatitis, as well as the problem of these mutations in HBV/human immunodeficiency virus and HBV/hepatitis C virus co-infected patients.
Publish Date	2014-06-27 10:37
Citation	Lazarevic I. Clinical implications of hepatitis B virus mutations: Recent advances. World J Gastroenterol 2014; 20(24): 7653-7664
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7653.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7653

Full Article (PDF)	WJG-20-7653.pdf
Full Article (Word)	WJG-20-7653.doc
Manuscript File	6771-Review.docx
Answering Reviewers	6771-Answering reviewers.pdf
Copyright License Agreement	6771-Copyright assignment.pdf
Peer-review Report	6771-Peer reviews.pdf
Scientific Editor Work List	6771-Scientific editor work list.doc