Publication Name	World Journal of Gastroenterology
Manuscript ID	6777
Country	Japan

Received	2013-10-29 09:09
Peer-Review Started	2013-10-29 22:13
To Make the First Decision	2013-12-26 11:37
Return for Revision	2013-12-27 15:11
Revised	2014-01-10 18:46
Second Decision	2014-04-03 10:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 11:29
Articles in Press	2014-05-23 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-09 15:33
Typeset the Manuscript	2014-08-21 16:52
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Topic Highlights
Article Title	Cellular physiological approach for treatment of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Atsushi Shiozaki, Daisuke Ichikawa, Eigo Otsuji and Yoshinori Marunaka
Funding Agency and Grant Number
Corresponding Author	Atsushi Shiozaki, Assistant Professor, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan. shiozaki@koto.kpu-m.ac.jp
Key Words	Gastric cancer; Ion channels; Water channels; Intracellular pH; Intracellular chloride; Osmolality
Core Tip	This article aims to systematically review the current knowledge on expression and functioning of ion transporters in gastric cancer (GC). Various types of ion channels, water channels and regulators of intracellular pH have been found to express in GC, and to control tumorigenesis. Our studies indicate the intracellular Cl- concentration could control cell cycle progression in GC cells. Further, we demonstrate the cytocidal effects of hypotonic shock, and indicate that regulation of ion transport enhances these effects. A deeper understanding of molecular mechanisms may lead to the discovery of these cellular physiological approaches as a novel therapeutic strategy for GC.
Publish Date	2014-09-07 13:31
Citation	Shiozaki A, Ichikawa D, Otsuji E, Marunaka Y. Cellular physiological approach for treatment of gastric cancer. World J Gastroenterol 2014; 20(33): 11560-11566
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11560.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11560

Full Article (PDF)	WJG-20-11560.pdf
Full Article (Word)	WJG-20-11560.doc
Manuscript File	6777-Review.docx
Answering Reviewers	6777-Answering reviewers.pdf
Copyright License Agreement	6777-Copyright assignment.pdf
Peer-review Report	6777-Peer review(s).pdf
Scientific Editor Work List	6777-Scientific editor work list.doc