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11/25/2021 8:31:20 AM | Browse: 280 | Download: 779
Publication Name World Journal of Stem Cells
Manuscript ID 67776
Country/Territory China
Received
2021-05-01 10:24
Peer-Review Started
2021-05-01 10:26
To Make the First Decision
Return for Revision
2021-06-16 03:59
Revised
2021-06-28 09:18
Second Decision
2021-09-02 02:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-02 09:18
Articles in Press
2021-09-02 09:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-11-09 10:36
Typeset the Manuscript
2021-11-22 05:42
Publish the Manuscript Online
2021-11-25 08:31
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation
Manuscript Source Invited Manuscript
All Author List Zhi-Wen Luo, Ya-Ying Sun, Jin-Rong Lin, Bei-Jie Qi and Ji-Wu Chen
ORCID
Author(s) ORCID Number
Zhi-Wen Luo http://orcid.org/0000-0002-0524-9951
Ya-Ying Sun http://orcid.org/0000-0001-5457-6046
Jin-Rong Lin http://orcid.org/0000-0001-5457-6045
Bei-Jie Qi http://orcid.org/0000-0002-4041-0050
Ji-Wu Chen http://orcid.org/0000-0003-1365-599X
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81772419
National Natural Science Foundation of China 81972062
Corresponding Author Ji-Wu Chen, MD, PhD, Academic Research, Chief Doctor, Professor, Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghai 200040, China. jeevechen@gmail.com
Key Words C2C12 myoblast; Exosomes; Macrophage polarization; Inflammation; Differentiation; Proliferation.
Core Tip For successful muscle regeneration, macrophage polarization and myogenesis should be supported by an appropriate combination of cells and their signals. As the communication between myoblast and macrophage within the inflammatory environment is unknown, we aimed to evaluate the effects of IF-C2C12-Exos on macrophage polarization and myoblast proliferation/differentiation. We found that IF-C2C12-Exos could induce M1 polarization, resulting in a sustained and exacerbated inflammatory environment, impair myoblast fibrogenic/myogenic differentiation, and lead to abnormal myogenic proliferation. These results indicate a potential mechanism for the development of long-term inflammation following acute muscle injury, but further preclinical evaluations targeting IF-C2C12-Exos in animal models are necessary.
Publish Date 2021-11-25 08:31
Citation Luo ZW, Sun YY, Lin JR, Qi BJ, Chen JW. Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation. World J Stem Cells 2021; 13(11): 1762-1782
URL https://www.wjgnet.com/1948-0210/full/v13/i11/1762.htm
DOI https://dx.doi.org/10.4252/wjsc.v13.i11.1762
Full Article (PDF) WJSC-13-1762.pdf
Full Article (Word) WJSC-13-1762.docx
The ARRIVE Guidelines 67776-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 67776_Auto_Edited-JPY-Webster J-2[25465]-Clear.docx
Answering Reviewers 67776-Answering reviewers.pdf
Audio Core Tip 67776-Audio core tip.m4a
Biostatistics Review Certificate 67776-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 67776-Conflict-of-interest statement.pdf
Copyright License Agreement 67776-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 67776-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 67776-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 67776-Language certificate.pdf
Supplementary Material 67776-Supplementary material.pdf
Peer-review Report 67776-Peer-review(s).pdf
Scientific Misconduct Check 67776-Bing-Fan JR-2.png
Scientific Misconduct Check 67776-Scientific misconduct check.pdf
Scientific Editor Work List 67776-Scientific editor work list.pdf