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Articles Published Processes
11/25/2021 8:31:20 AM | Browse: 432 | Download: 1273
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Received |
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2021-05-01 10:24 |
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Peer-Review Started |
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2021-05-01 10:26 |
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To Make the First Decision |
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Return for Revision |
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2021-06-16 03:59 |
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Revised |
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2021-06-28 09:18 |
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Second Decision |
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2021-09-02 02:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-02 09:18 |
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Articles in Press |
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2021-09-02 09:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-11-09 10:36 |
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Typeset the Manuscript |
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2021-11-22 05:42 |
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Publish the Manuscript Online |
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2021-11-25 08:31 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhi-Wen Luo, Ya-Ying Sun, Jin-Rong Lin, Bei-Jie Qi and Ji-Wu Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81772419 |
| National Natural Science Foundation of China |
81972062 |
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| Corresponding Author |
Ji-Wu Chen, MD, PhD, Academic Research, Chief Doctor, Professor, Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghai 200040, China. jeevechen@gmail.com |
| Key Words |
C2C12 myoblast; Exosomes; Macrophage polarization; Inflammation; Differentiation; Proliferation. |
| Core Tip |
For successful muscle regeneration, macrophage polarization and myogenesis should be supported by an appropriate combination of cells and their signals. As the communication between myoblast and macrophage within the inflammatory environment is unknown, we aimed to evaluate the effects of IF-C2C12-Exos on macrophage polarization and myoblast proliferation/differentiation. We found that IF-C2C12-Exos could induce M1 polarization, resulting in a sustained and exacerbated inflammatory environment, impair myoblast fibrogenic/myogenic differentiation, and lead to abnormal myogenic proliferation. These results indicate a potential mechanism for the development of long-term inflammation following acute muscle injury, but further preclinical evaluations targeting IF-C2C12-Exos in animal models are necessary. |
| Publish Date |
2021-11-25 08:31 |
| Citation |
Luo ZW, Sun YY, Lin JR, Qi BJ, Chen JW. Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation. World J Stem Cells 2021; 13(11): 1762-1782 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i11/1762.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i11.1762 |
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