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Publication Name World Journal of Gastroenterology
Manuscript ID 6779
Country/Territory United States
Received
2013-10-29 09:16
Peer-Review Started
2013-10-29 22:28
To Make the First Decision
2013-12-16 17:37
Return for Revision
2013-12-17 19:28
Revised
2013-12-28 14:12
Second Decision
2014-01-20 18:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 19:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-16 13:53
Publish the Manuscript Online
2014-04-17 13:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Targeting mTOR network in colorectal cancer therapy
Manuscript Source Invited Manuscript
All Author List Xiao-Wen Wang and Yan-Jie Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Nature Science Foundation 81270035
Supported by National Nature Science Foundation, No. 81270035; and International Cooperation 11410708100
Corresponding Author Yan-Jie Zhang, MD, PhD, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, United States. zhang26@cinj.rutgers.edu
Key Words Mechanistic target of rapamycin pathway; Colorectal cancer; Mechanistic target of rapamycin inhibitor; Chemotherapy; Drug resistance
Core Tip Mechanistic target of rapamycin (mTOR) pathway serves as a central regulating axis that coordinates cell growth and proliferation. Single-agent mTOR inhibition therapy, however, has provided only limited therapeutic efficacy towards colorectal cancer. Blocking compensatory pathways and multiple feedback loops is considered the challenge. Combination regimens are being intensively tested in clinic. This review summarizes extensive studies describing crosstalk between mTOR pathway and major oncogenic pathways contributing to colorectal cancer development and novel combinational strategies targeting the mTOR pathway in treating colorectal cancer are also introduced.
Publish Date 2014-04-17 13:27
Citation Wang XW, Zhang YJ. Targeting mTOR network in colorectal cancer therapy. World J Gastroenterol 2014; 20(15): 4178-4188
URL http://www.wjgnet.com/1007-9327/full/v20/i15/4178.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i15.4178
Full Article (PDF) WJG-20-4178.pdf
Full Article (Word) WJG-20-4178.doc
Manuscript File 6779-Review.docx
Answering Reviewers 6779-Answering reviewers.pdf
Copyright License Agreement 6779-Copyright assignment.pdf
Peer-review Report 6779-Peer review (s).pdf
Scientific Editor Work List 6779-Scientific editor work list.doc