Publication Name	World Journal of Gastroenterology
Manuscript ID	6779
Country	United States

Received	2013-10-29 09:16
Peer-Review Started	2013-10-29 22:28
To Make the First Decision	2013-12-16 17:37
Return for Revision	2013-12-17 19:28
Revised	2013-12-28 14:12
Second Decision	2014-01-20 18:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-16 13:53
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Targeting mTOR network in colorectal cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Xiao-Wen Wang and Yan-Jie Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Nature Science Foundation 81270035 Supported by National Nature Science Foundation, No. 81270035; and International Cooperation 11410708100
Corresponding Author	Yan-Jie Zhang, MD, PhD, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, United States. zhang26@cinj.rutgers.edu
Key Words	Mechanistic target of rapamycin pathway; Colorectal cancer; Mechanistic target of rapamycin inhibitor; Chemotherapy; Drug resistance
Core Tip	Mechanistic target of rapamycin (mTOR) pathway serves as a central regulating axis that coordinates cell growth and proliferation. Single-agent mTOR inhibition therapy, however, has provided only limited therapeutic efficacy towards colorectal cancer. Blocking compensatory pathways and multiple feedback loops is considered the challenge. Combination regimens are being intensively tested in clinic. This review summarizes extensive studies describing crosstalk between mTOR pathway and major oncogenic pathways contributing to colorectal cancer development and novel combinational strategies targeting the mTOR pathway in treating colorectal cancer are also introduced.
Publish Date	2014-04-17 13:27
Citation	Wang XW, Zhang YJ. Targeting mTOR network in colorectal cancer therapy. World J Gastroenterol 2014; 20(15): 4178-4188
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4178.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4178

Full Article (PDF)	WJG-20-4178.pdf
Full Article (Word)	WJG-20-4178.doc
Manuscript File	6779-Review.docx
Answering Reviewers	6779-Answering reviewers.pdf
Copyright License Agreement	6779-Copyright assignment.pdf
Peer-review Report	6779-Peer review (s).pdf
Scientific Editor Work List	6779-Scientific editor work list.doc