Publication Name	World Journal of Gastroenterology
Manuscript ID	67855
Country	Italy

Received	2021-05-04 09:01
Peer-Review Started	2021-05-04 09:04
To Make the First Decision
Return for Revision	2021-06-12 05:05
Revised	2021-06-13 17:38
Second Decision	2021-09-07 03:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-09-08 18:26
Articles in Press	2021-09-08 18:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-23 08:22
Typeset the Manuscript	2021-12-01 01:57
Publish the Manuscript Online	2021-12-03 07:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	SARS-CoV-2 infection in people with pre-existing liver disease: Further research is warranted
Manuscript Source	Invited Manuscript
All Author List	Henu Kumar Verma and LVKS Bhaskar
ORCID	Author(s) ORCID Number Henu Kumar Verma http://orcid.org/0000-0003-1130-8783 LVKS Bhaskar http://orcid.org/0000-0003-2977-6454
Funding Agency and Grant Number
Corresponding Author	Henu Kumar Verma, PhD, Research Scientist, Department of Immunopathology, Institute of lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, Neuherberg 85764, Munich, Germany. henu.verma@yahoo.com
Key Words	Cytokine storm; Liver disease; Angiotensin-converting enzyme 2; Therapeutics; Inflammatory markers
Core Tip	Understanding the hepatic consequences of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and its molecular mechanism has greatly evolved. Evidence suggests that coronavirus disease 2019 (COVID-19) fatalities are primarily due to cytokine storm and abnormal immune function. Throughout the infection, interleukin-6, nuclear factor kappa B, and tumor necrosis factor-alpha are inflammatory cytokines released by SARS-CoV-2-infected macrophages and monocytes that cause acute liver injury. Anti-viral treatment with anti-inflammatory receptors, such as monoclonal antibodies, can be used to reduce the morbidity and mortality associated with COVID-19 infection.
Publish Date	2021-12-03 07:34
Citation	Verma HK, Bhaskar L. SARS-CoV-2 infection in people with pre-existing liver disease: Further research is warranted. World J Gastroenterol 2021; 27(45): 7855-7858
URL	https://www.wjgnet.com/2219-2840/full/v27/i45/7855.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i45.7855

Full Article (PDF)	WJG-27-7855.pdf
Full Article (Word)	WJG-27-7855.docx
Manuscript File	67855_Auto_Edited_WangTQ.docx
Answering Reviewers	67855-Answering reviewers.pdf
Audio Core Tip	67855-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67855-Conflict-of-interest statement.pdf
Copyright License Agreement	67855-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67855-Language certificate.pdf
Peer-review Report	67855-Peer-review(s).pdf
Scientific Misconduct Check	67855-Bing-Fan JR-2.png
Scientific Editor Work List	67855-Scientific editor work list.pdf
CrossCheck Report	67855-CrossCheck report.pdf
CrossCheck Report	67855-CrossCheck.png