Publication Name	World Journal of Gastroenterology
Manuscript ID	6787
Country	Canada

Received	2013-10-29 09:51
Peer-Review Started	2013-10-29 22:53
To Make the First Decision	2013-12-26 11:36
Return for Revision	2013-12-27 15:18
Revised	2014-02-16 04:54
Second Decision	2014-04-09 08:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-09 09:02
Articles in Press	2014-05-23 10:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-10 10:07
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Potential role of metabolomics in diagnosis and surveillance of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Angela W Chan, Richdeep S Gill, Daniel Schiller and Michael B Sawyer
Funding Agency and Grant Number
Corresponding Author	Michael B Sawyer, Associate Professor of Oncology, Division of Medical Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada. michael.sawyer@albertahealthservices.ca
Key Words	Gastric cancer; Metabolomics; Screening; Biomarkers; Surveillance
Core Tip	There are differences in metabolomic profiles of gastric cancer patients and healthy controls, as well as between different stages of gastric cancer. The transition from normal to malignant consistently shows upregulation in lactate and downregulation of glucose consistent with the Warburg effect. This trend is perpetuated as cells advance from non-invasive to invasive. Key tricarboxylic acid (TCA) cycle intermediates and amino acids are elevated as a result of anaplerotic reactions. Perpetuation of the TCA cycle generates energy for essential cell functions. There is less consistency between lipid and nucleic acid metabolites.
Publish Date	2014-10-01 20:25
Citation	Chan AW, Gill RS, Schiller D, Sawyer MB. Potential role of metabolomics in diagnosis and surveillance of gastric cancer. World J Gastroenterol 2014; 20(36): 12874-12882
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/12874.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.12874

Full Article (PDF)	WJG-20-12874.pdf
Full Article (Word)	WJG-20-12874.doc
Manuscript File	6787-Review.docx
Answering Reviewers	6787-Answering reviewers.pdf
Copyright License Agreement	6787-Copyright assignment.PDF
Peer-review Report	6787-Peer review(s).pdf
Scientific Editor Work List	6787-Scientific editor work list.doc