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10/1/2014 8:25:00 PM | Browse: 1127 | Download: 1051
Publication Name World Journal of Gastroenterology
Manuscript ID 6787
Country/Territory Canada
Received
2013-10-29 09:51
Peer-Review Started
2013-10-29 22:53
To Make the First Decision
2013-12-26 11:36
Return for Revision
2013-12-27 15:18
Revised
2014-02-16 04:54
Second Decision
2014-04-09 08:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-09 09:02
Articles in Press
2014-05-23 10:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-10 10:07
Publish the Manuscript Online
2014-10-01 20:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Potential role of metabolomics in diagnosis and surveillance of gastric cancer
Manuscript Source Invited Manuscript
All Author List Angela W Chan, Richdeep S Gill, Daniel Schiller and Michael B Sawyer
Funding Agency and Grant Number
Corresponding Author Michael B Sawyer, Associate Professor of Oncology, Division of Medical Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada. michael.sawyer@albertahealthservices.ca
Key Words Gastric cancer; Metabolomics; Screening; Biomarkers; Surveillance
Core Tip There are differences in metabolomic profiles of gastric cancer patients and healthy controls, as well as between different stages of gastric cancer. The transition from normal to malignant consistently shows upregulation in lactate and downregulation of glucose consistent with the Warburg effect. This trend is perpetuated as cells advance from non-invasive to invasive. Key tricarboxylic acid (TCA) cycle intermediates and amino acids are elevated as a result of anaplerotic reactions. Perpetuation of the TCA cycle generates energy for essential cell functions. There is less consistency between lipid and nucleic acid metabolites.
Publish Date 2014-10-01 20:25
Citation Chan AW, Gill RS, Schiller D, Sawyer MB. Potential role of metabolomics in diagnosis and surveillance of gastric cancer. World J Gastroenterol 2014; 20(36): 12874-12882
URL http://www.wjgnet.com/1007-9327/full/v20/i36/12874.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i36.12874
Full Article (PDF) WJG-20-12874.pdf
Full Article (Word) WJG-20-12874.doc
Manuscript File 6787-Review.docx
Answering Reviewers 6787-Answering reviewers.pdf
Copyright License Agreement 6787-Copyright assignment.PDF
Peer-review Report 6787-Peer review(s).pdf
Scientific Editor Work List 6787-Scientific editor work list.doc