Publication Name	World Journal of Diabetes
Manuscript ID	67981
Country	China

Received	2021-07-07 10:16
Peer-Review Started	2021-07-07 10:16
To Make the First Decision
Return for Revision	2021-07-28 04:52
Revised	2021-08-09 14:17
Second Decision	2021-12-06 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-08 06:07
Articles in Press	2021-12-08 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-25 18:55
Typeset the Manuscript	2021-12-13 06:43
Publish the Manuscript Online	2021-12-16 07:46

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Ophthalmology
Manuscript Type	Basic Study
Article Title	Inhibitory effect of maspinon neovascularization in diabetic retinopathy
Manuscript Source	Unsolicited Manuscript
All Author List	Feng Qiu and Hui-Juan Tong
ORCID	Author(s) ORCID Number Feng Qiu http://orcid.org/0000-0001-7634-721X Hui-Juan Tong http://orcid.org/0000-0002-9733-5602
Funding Agency and Grant Number	Funding Agency Grant Number Liaoning Province Natural Science Foundation 2020-BS-277
Corresponding Author	Hui-Juan Tong, PhD, Assistant Professor, Department of Nursing, Shenyang Medical College, No. 146 North Huanghe Avenue, Shenyang 110034, Liaoning Province, China. thj_9921@163.com
Key Words	Maspin; Diabetic retinopathy; Neovascularization; Vascular endothelial growth factor; Hypoxia-inducible factor 1-alpha
Core Tip	The aim of our study was to evaluate the effectiveness of intravitreal injection of recombinant human maspin on neovascularization in diabetic retinopathy. A mouse model of oxygen-induced retinopathy was used to simulate neovascularization in diabetic retinopathy. Maspin inhibited neovascularization in this model by modulating the hypoxia-inducible factor 1-alpha/vascular endothelial growth factor pathway, which provides a potential and effective strategy for the treatment of diabetic retinopathy.
Publish Date	2021-12-16 07:46
Citation	Qiu F, Tong HJ. Inhibitory effect of maspin on neovascularization in diabetic retinopathy. World J Diabetes 2021; 12(12): 2050-2057
URL	https://www.wjgnet.com/1948-9358/full/v12/i12/2050.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i12.2050

Full Article (PDF)	WJD-12-2050.pdf
Full Article (Word)	WJD-12-2050.docx
The ARRIVE Guidelines	67981-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	67981_Auto_Edited-JLW-Filipodia.docx
Answering Reviewers	67981-Answering reviewers.pdf
Audio Core Tip	67981-Audio core tip.m4a
Biostatistics Review Certificate	67981-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	67981-Conflict-of-interest statement.pdf
Copyright License Agreement	67981-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67981-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	67981-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	67981-Language certificate.pdf
Peer-review Report	67981-Peer-review(s).pdf
Scientific Editor Work List	67981-Scientific editor work list.pdf
CrossCheck Report	67981-CrossCheck report.pdf