Publication Name	World Journal of Gastroenterology
Manuscript ID	6810
Country	Italy

Received	2013-10-29 11:17
Peer-Review Started	2013-10-29 20:34
To Make the First Decision	2013-11-21 19:08
Return for Revision	2013-11-22 10:26
Revised	2013-11-29 21:19
Second Decision	2014-01-15 20:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-15 20:30
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-06 16:17
Publish the Manuscript Online	2014-05-18 12:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Reproductive Biology
Manuscript Type	Topic Highlights
Article Title	Can Helicobacter pylori infection influence human reproduction?
Manuscript Source	Invited Manuscript
All Author List	Elena Moretti, Natale Figura, Giulia Collodel and Antonio Ponzetto
Funding Agency and Grant Number
Corresponding Author	Natale Figura, Professor, Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S Maria alle Scotte, Viale Mario Bracci 16, 53100 Siena, Italy. natale.figura@unisi.it
Key Words	Antigenic mimicry; Helicobacter pylori infection; Human sperm; Inflammatory cytokines; Preeclampsia; Reproductive disorders
Core Tip	The evidences that Helicobacter pylori (H. pylori) infection may have a role in decreasing human reproductive potential are steadily increasing. Sperm quality of men infected by H. pylori strains expressing CagA is reduced. Infected women have specific antibodies in cervical mucus, which decrease sperm motility, as well as in follicular fluids, which may cross react with sperm. In women with polycystic ovary syndrome and preeclampsia the prevalence of H. pylori infection is increased. The putative pathogenic mechanisms that account for these observations include elevated inflammatory cytokine levels in infected individuals and phenomena of antigenic mimicry between bacterial antigens and human proteins.
Publish Date	2014-05-18 12:31
Citation	Moretti E, Figura N, Collodel G, Ponzetto A. Can Helicobacter pylori infection influence human reproduction? World J Gastroenterol 2014; 20(19): 5567-5574
URL	http://www.wjgnet.com/1007-9327/full/v20/i19/5567.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i19.5567

Full Article (PDF)	WJG-20-5567.pdf
Full Article (Word)	WJG-20-5567.doc
Manuscript File	6810-Review.docx
Answering Reviewers	6810-Answering review.pdf
Copyright License Agreement	6810-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131028162557.docx
Non-Native Speakers of English Editing Certificate	6810-Language certificate.pdf
Peer-review Report	6810-Peer review(s).pdf
Scientific Editor Work List	6810-Scientific editor work list.doc