Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	68162
Country	Chile

Received	2021-05-13 15:44
Peer-Review Started	2021-05-13 15:47
To Make the First Decision
Return for Revision	2021-06-05 16:14
Revised	2021-06-10 15:45
Second Decision	2021-10-27 09:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-27 21:33
Articles in Press	2021-10-27 21:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-07 04:42
Publish the Manuscript Online	2021-12-14 23:58

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Armando Rojas, Cristian Lindner, Iván Schneider, Ileana Gonzàlez, Hernan Araya, Erik Morales, Milibeth Gómez, Nelson Urdaneta, Paulina Araya and Miguel Angel Morales
ORCID	Author(s) ORCID Number Armando Rojas http://orcid.org/0000-0001-9911-7142 Cristian Lindner http://orcid.org/0000-0002-2642-4288 Iván Schneider http://orcid.org/0000-0001-5294-5995 Ileana Gonzàlez http://orcid.org/0000-0002-2488-9380 Hernan Araya http://orcid.org/0000-0002-0758-4040 Erik Morales http://orcid.org/0000-0002-0271-2787 Milibeth Gómez http://orcid.org/0000-0002-7548-2337 Nelson Urdaneta http://orcid.org/0000-0003-2626-6010 Paulina Araya http://orcid.org/0000-0002-6797-3056 Miguel Angel Morales http://orcid.org/0000-0001-7698-9669
Funding Agency and Grant Number
Corresponding Author	Armando Rojas, PhD, Full Professor, Biomedical Research Lab., Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca 34600000, Chile. arojasr@ucm.cl
Key Words	Diabetes mellitus; Gastric cancer; Tumor microenvironment; Hyperglycemia; Chronic inflammation
Core Tip	Compelling shreds of evidence support that diabetes mellitus (DM) is a crucial risk factor in human cancers. Due to its contribution to systemic inflammation, DM can sculpture the gastric tumor microenvironment through different mechanisms, which in turn, may generate highly malignant phenotypes in gastric cancer. We herein discuss the contribution of DM in the remodeling tumor microenvironment in GC, which may then leads to more aggressive tumor phenotypes.
Publish Date	2021-12-14 23:58
Citation	Rojas A, Lindner C, Schneider I, Gonzàlez I, Araya H, Morales E, Gómez M, Urdaneta N, Araya P, Morales MA. Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer. World J Gastrointest Oncol 2021; 13(12): 1997-2012
URL	https://www.wjgnet.com/1948-5204/full/v13/i12/1997.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i12.1997

Full Article (PDF)	WJGO-13-1997.pdf
Full Article (Word)	WJGO-13-1997.docx
Manuscript File	68162_Auto_Edited.docx
Answering Reviewers	68162-Answering reviewers.pdf
Audio Core Tip	68162-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	68162-Conflict-of-interest statement.pdf
Copyright License Agreement	68162-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	68162-Language certificate.pdf
Peer-review Report	68162-Peer-review(s).pdf
Scientific Editor Work List	68162-Scientific editor work list.pdf