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Articles Published Processes
3/24/2022 2:13:21 PM | Browse: 477 | Download: 1567
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Received |
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2021-05-18 15:49 |
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Peer-Review Started |
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2021-05-18 15:52 |
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To Make the First Decision |
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Return for Revision |
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2021-06-25 09:49 |
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Revised |
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2021-07-04 11:52 |
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Second Decision |
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2022-02-14 05:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-16 07:20 |
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Articles in Press |
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2022-02-16 07:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-01-28 22:15 |
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Typeset the Manuscript |
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2022-03-17 13:16 |
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Publish the Manuscript Online |
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2022-03-24 14:13 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Predictors of mortality at 28-days in infection associated acute kidney injury in cirrhosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tarana Gupta, Naveen Ranga and Sandeep Kumar Goyal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tarana Gupta, MBBS, MD, Doctor, Doctor, Professor, Department of Medicine, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Medical Mor, Rohtak 124001, Haryana, India. taranagupta@gmail.com |
| Key Words |
Infection; Acute kidney injury; Mortality; Cirrhosis; Bilirubin; Hepatic encephalopathy |
| Core Tip |
The infections in cirrhosis are the most common cause for acute decompensation and organ failure. Acute kidney injury (AKI) in cirrhosis is itself an indicator for worsening hemodynamics. In the present study, we compared infection associated AKI and non-infection AKI. We found higher 28-d mortality in infection AKI than non-infection AKI. In addition to altered hemodynamics, pathogen associated molecular patterns and damage-associated molecular patterns produced as a result of sepsis contribute to multiorgan failure, especially renal dysfunction. Moreover, higher bilirubin and presence of hepatic encephalopathy predicted 28-d mortality in patients with infection AKI. This provides an insight that the combination of infection and AKI in cirrhosis portends a dismal prognosis and therefore, on admission, early identification of infection and aggressive management may improve outcome in these patients. |
| Publish Date |
2022-03-24 14:13 |
| Citation |
Gupta T, Ranga N, Goyal SK. Predictors of mortality at 28-days in infection associated acute kidney injury in cirrhosis. World J Hepatol 2022; 14(3): 592-601 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i3/592.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i3.592 |
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