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Articles Published Processes
1/21/2022 8:16:14 AM | Browse: 1018 | Download: 2357
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Received |
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2021-05-15 14:33 |
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Peer-Review Started |
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2021-05-15 14:37 |
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First Decision by Editorial Office Director |
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2021-07-08 07:05 |
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Return for Revision |
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2021-07-08 07:05 |
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Revised |
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2021-07-10 00:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-12-31 03:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-12-31 22:23 |
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Articles in Press |
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2021-12-31 22:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-18 04:33 |
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Publish the Manuscript Online |
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2022-01-21 08:16 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anil Alpsoy, Haydar Adanir, Zeynep Bayramoglu and Gulsum Ozlem Elpek |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University, Medical School, Dumlupınar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr |
| Key Words |
Hepatitis B; Hepatitis B surface antigens; Hepatitis B e antigens; Fibrosis; Immunohistochemistry; Image analysis |
| Core Tip |
This report describes a study that investigated image analysis-based quantitative hepatitis B surface antigen (HBsAg) expression and its different staining patterns in liver biopsies from patients with chronic viral B hepatitis (CHB) and correlated them with clinicopathological factors and treatment. Our findings confirmed the association of cytoplasmic HBsAg staining patterns with disease activity. Besides, the determination of immunohistochemical HBsAg expression by image analysis may be an important predictor of the response to therapy, especially in hepatitis B e antigen-positive cases. Accordingly, evaluation of the percentage of HBsAg expression by objective methods in liver tissues from treatment-naïve CHB patients might provide a useful tool in the follow-up and treatment of this disease. |
| Publish Date |
2022-01-21 08:16 |
| Citation |
Alpsoy A, Adanir H, Bayramoglu Z, Elpek GO. Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study. World J Hepatol 2022; 14(1): 260-273
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| URL |
https://www.wjgnet.com/1948-5182/full/v14/i1/260.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i1.260 |
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