Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	68218
Country	China

Received	2021-05-20 08:34
Peer-Review Started	2021-05-20 08:37
To Make the First Decision
Return for Revision	2021-06-12 03:42
Revised	2021-06-17 09:27
Second Decision	2021-07-05 12:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-05 14:32
Articles in Press	2021-07-05 14:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-15 08:12
Typeset the Manuscript	2021-08-11 14:34
Publish the Manuscript Online	2021-08-14 11:08

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	STAT3-mediated activation of mitochondrial pathway contributes to antitumor effect of dihydrotanshinone I in esophageal squamous carcinoma cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Ming Qi, Peng-Zhan He, Lan Zhang and Wei-Guo Dong
ORCID	Author(s) ORCID Number Ming-Ming Qi http://orcid.org/0000-0001-8393-4367 Peng-Zhan He http://orcid.org/0000-0002-6971-1068 Lan Zhang http://orcid.org/0000-0002-3488-4620 Wei-Guo Dong http://orcid.org/0000-0002-4228-6508
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81572426 National Natural Science Foundation of China 81870392 National Natural Science Foundation of China 82000521
Corresponding Author	Wei-Guo Dong, MD, PhD, Professor, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China, Wuhan 430060, Hubei Province, China. dongweiguo@whu.edu.cn
Key Words	Esophageal squamous cell carcinoma; Dihydrotanshinone I; STAT3; Proliferation; Apoptosis
Core Tip	Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies with a poor prognosis. Our research found that dihydrotanshinone I (DHTS) suppresses proliferation and induces apoptosis in ESCC cells. Besides, STAT3-mediated activation of mitochondrial pathway plays a vital role in DHTS-induced apoptosis. DHTS may be a promising candidate for the treatment of ESCC.
Publish Date	2021-08-14 11:08
Citation	Qi MM, He PZ, Zhang L, Dong WG. STAT3-mediated activation of mitochondrial pathway contributes to antitumor effect of dihydrotanshinone I in esophageal squamous cell carcinoma cells. World J Gastrointest Oncol 2021; 13(8): 893-914
URL	https://www.wjgnet.com/1948-5204/full/v13/i8/893.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i8.893

Full Article (PDF)	WJGO-13-893.pdf
Full Article (Word)	WJGO-13-893.docx
The ARRIVE Guidelines	68218-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	68218_Auto_Edited-ZMG_WangTQ.docx
Answering Reviewers	68218-Answering reviewers.pdf
Audio Core Tip	68218-Audio core tip.m4a
Biostatistics Review Certificate	68218-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	68218-Conflict-of-interest statement.pdf
Copyright License Agreement	68218-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	68218-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	68218-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	68218-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	68218-Language certificate.pdf
Peer-review Report	68218-Peer-review(s).pdf
Scientific Misconduct Check	68218-Scientific misconduct check.pdf
Scientific Editor Work List	68218-Scientific editor work list.pdf
CrossCheck Report	68218-CrossCheck report.pdf