Publication Name	World Journal of Biological Chemistry
Manuscript ID	6833
Country	France

Received	2013-10-29 12:55
Peer-Review Started	2013-10-29 17:55
To Make the First Decision	2013-11-12 14:28
Return for Revision	2013-11-13 14:54
Revised	2013-11-22 23:58
Second Decision	2013-12-19 12:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-12-19 13:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-02 20:36
Typeset the Manuscript	2014-02-26 11:21
Publish the Manuscript Online	2014-03-19 21:35

ISSN	1949-8454 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment
Manuscript Source	Invited Manuscript
All Author List	Andrii Vislovukh, Thaiz Rivera Vargas, Anna Polesskaya and Irina Groisman
Funding Agency and Grant Number
Corresponding Author	Irina Groisman, PhD, Commissariat à l’Energie Atomique (CEA), Saclay, Bat. 144-Point courrier n 22, F-91191 Gif-sur-Yvette, France. irina.groisman@cea.fr
Key Words	Translational control; 3’-untranslated region; MicroRNAs; RNA binding proteins; Cancer
Core Tip	The messenger RNA 3’-untranslated region (3’UTR) plays an important role in regulation of gene expression on the posttranscriptional level. 3’UTR controls gene expression via orchestrated interaction between structural components mRNAs (cis-element) and specific trans-acting factors (RNA binding proteins and non-coding RNAs). Alteration of any of these components can lead to various pathologies. In this review we will discuss how alteration of these factors or a change in the crosstalk between them can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these regulatory mechanisms and their impact on 3’UTR-directed posttranscriptional gene regulation may uncover promising new targets for therapeutic intervention and diagnostics.
Publish Date	2014-03-19 21:35
Citation	Vislovukh A, Vargas TR, Polesskaya A, Groisman I. Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment. World J Biol Chem 2014; 5(1): 40-57 Available from: URL: http://www.wjgnet.com/1949-8454/full/v5/i1/40.htm DOI: http://dx.doi.org/10.4331/wjbc.v5.i1.40
URL	http://www.wjgnet.com/1949-8454/full/v5/i1/40.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i1.40

Full Article (PDF)	wjbc-5-40.pdf
Full Article (Word)	wjbc-5-40.doc
Manuscript File	6833-Review.docx
Answering Reviewers	6833-Answering reviewers.pdf
Copyright License Agreement	6833-Copyright assignment.pdf
Peer-review Report	6833-Peer review(s).pdf
Scientific Editor Work List	6833-Scientific editor work list.doc