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8/27/2014 4:30:00 PM | Browse: 558 | Download: 263
Publication Name World Journal of Biological Chemistry
Manuscript ID 6833
Country/Territory France
Received
2013-10-29 12:55
Peer-Review Started
2013-10-29 17:55
To Make the First Decision
2013-11-12 14:28
Return for Revision
2013-11-13 14:54
Revised
2013-11-22 23:58
Second Decision
2013-12-19 12:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-12-19 13:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-01-02 20:36
Typeset the Manuscript
2014-02-26 11:21
Publish the Manuscript Online
2014-03-19 21:35
ISSN 1949-8454 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment
Manuscript Source Invited Manuscript
All Author List Andrii Vislovukh, Thaiz Rivera Vargas, Anna Polesskaya and Irina Groisman
Funding Agency and Grant Number
Corresponding author Irina Groisman, PhD, Commissariat à l’Energie Atomique (CEA), Saclay, Bat. 144-Point courrier n 22, F-91191 Gif-sur-Yvette, France. irina.groisman@cea.fr
Keywords Translational control; 3’-untranslated region; MicroRNAs; RNA binding proteins; Cancer
Core Tip The messenger RNA 3’-untranslated region (3’UTR) plays an important role in regulation of gene expression on the posttranscriptional level. 3’UTR controls gene expression via orchestrated interaction between structural components mRNAs (cis-element) and specific trans-acting factors (RNA binding proteins and non-coding RNAs). Alteration of any of these components can lead to various pathologies. In this review we will discuss how alteration of these factors or a change in the crosstalk between them can affect cancer development and promote or enhance the malignant phenotype of cancer cells. Understanding these regulatory mechanisms and their impact on 3’UTR-directed posttranscriptional gene regulation may uncover promising new targets for therapeutic intervention and diagnostics.
Publish Date 2014-03-19 21:35
Citation Vislovukh A, Vargas TR, Polesskaya A, Groisman I. Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment. World J Biol Chem 2014; 5(1): 40-57 Available from: URL: http://www.wjgnet.com/1949-8454/full/v5/i1/40.htm DOI: http://dx.doi.org/10.4331/wjbc.v5.i1.40
Url http://www.wjgnet.com/1949-8454/full/v5/i1/40.htm
DOI http://dx.doi.org/10.4331/wjbc.v5.i1.40
Full Article (PDF) wjbc-5-40.pdf
Full Article (Word) wjbc-5-40.doc
Manuscript File 6833-Review.docx
Answering Reviewers 6833-Answering reviewers.pdf
Copyright License Agreement 6833-Copyright assignment.pdf
Peer-review Report 6833-Peer review(s).pdf
Scientific Editor Work List 6833-Scientific editor work list.doc