Publication Name	World Journal of Hepatology
Manuscript ID	68421
Country	India

Received	2021-05-22 10:48
Peer-Review Started	2021-05-22 10:53
To Make the First Decision
Return for Revision	2021-07-06 02:07
Revised	2021-07-17 19:19
Second Decision	2021-11-30 03:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-30 19:14
Articles in Press	2021-11-30 19:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-18 04:32
Publish the Manuscript Online	2022-01-21 08:16

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Recent updates on progressive familial intrahepatic cholestasis types 1, 2 and 3: Outcome and therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Seema Alam and Bikrant Bihari Lal
ORCID	Author(s) ORCID Number Seema Alam http://orcid.org/0000-0003-0888-8625 Bikrant Bihari Lal http://orcid.org/0000-0001-6275-7736
Funding Agency and Grant Number
Corresponding Author	Seema Alam, MD, Professor, Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D-1 Vasant Kunj, New Delhi 110070, India. seema_alam@hotmail.com
Key Words	Genotype; Biliary diversion; Gene therapy; Liver transplantation
Core Tip	The spectrum of clinical manifestations in progressive familial intrahepatic cholestasis varies from mild to severe leading to end stage liver disease necessitating liver transplantation. Medical therapy forms the mainstay of treatment of pruritus with surgical biliary diversion reserved for refractory cases. Apical sodium bile salt co-transporter inhibitors are among the most promising newer drugs. This article describes the recent advances in understanding the clinical course and emerging therapies.
Publish Date	2022-01-21 08:16
Citation	Alam S, Lal BB. Recent updates on progressive familial intrahepatic cholestasis types 1, 2 and 3: Outcome and therapeutic strategies. World J Hepatol 2022; 14(1): 98-118
URL	https://www.wjgnet.com/1948-5182/full/v14/i1/98.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i1.98

Full Article (PDF)	WJH-14-98.pdf
Full Article (Word)	WJH-14-98.docx
Manuscript File	68421_Auto_Edited.docx
Answering Reviewers	68421-Answering reviewers.pdf
Audio Core Tip	68421-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	68421-Conflict-of-interest statement.pdf
Copyright License Agreement	68421-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	68421-Language certificate.pdf
Peer-review Report	68421-Peer-review(s).pdf
Scientific Misconduct Check	68421-Bing-Wang JJ-2.png
Scientific Editor Work List	68421-Scientific editor work list.pdf
CrossCheck Report	68421-CrossCheck report.pdf