| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Case Report |
| Article Title |
Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: Report of six cases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Tian, Yi Lyu, Bo Wang, Chang Liu, Liang Yu, Jian-Hua Shi, Xue-Min Liu, Xiao-Gang Zhang, Kun Guo, Yu Li and Liang-Shuo Hu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81870445 |
| Scientific Research Project of Military Healthcare |
BZZ19J004 |
|
| Corresponding Author |
Bo Wang, MD, PhD, Chief Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. bobwang75@sina.com |
| Key Words |
Graft-versus-host disease; Liver transplantation; Donor T-lymphocytes chimerism; Gut microbiota; Donor-targeted serotherapy; Case report |
| Core Tip |
Acute graft-versus-host disease (aGVHD) is rare after liver transplantation (LT) with an incidence rate of 0.57% and the high mortality (up to 83.33%), which poses a critical challenge to our hospital. The diagnosis of aGVHD mainly depends on clinical symptoms, laboratory examinations especially donor T-lymphocytes chimerism analysis and histopathological. The larger the age distribution and the earlier the first symptoms, it is herald that the more rapid the progression in post-LT aGVHD. The most appear steroid-resistant in post-LT aGVHD. Thus, lower the dose of the corticosteroids, improved antibiotic stewardship, Particularly, gut microbial interventions and donor-targeted serotherapy may provide novel therapeutics. |
| Publish Date |
2021-10-21 08:44 |
| Citation |
Tian M, Lyu Y, Wang B, Liu C, Yu L, Shi JH, Liu XM, Zhang XG, Guo K, Li Y, Hu LS. Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: Report of six cases. World J Clin Cases 2021; 9(30): 9255-9268 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i30/9255.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i30.9255 |
