Publication Name	World Journal of Clinical Cases
Manuscript ID	68886
Country	China

Received	2021-12-13 07:21
Peer-Review Started	2021-12-13 07:23
To Make the First Decision
Return for Revision	2022-01-12 03:54
Revised	2022-01-21 10:40
Second Decision	2022-03-30 02:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-04-04 03:30
Articles in Press	2022-04-04 03:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-21 22:21
Typeset the Manuscript	2022-04-21 07:57
Publish the Manuscript Online	2022-06-02 10:05

ISSN	2307-8960 (online)
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Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Case Report
Article Title	Crouzon syndrome in a fraternal twin: A case report and review of the literature
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Jing Li, Ji-Mei Su and Xiao-Wei Ye
ORCID	Author(s) ORCID Number Xiao-Jing Li http://orcid.org/0000-0002-8122-9450 Ji-Mei Su http://orcid.org/0000-0001-9429-617X Xiao-Wei Ye http://orcid.org/0000-0003-0518-5801
Funding Agency and Grant Number
Corresponding Author	Ji-Mei Su, MD, Chief Doctor, Department of Stomatology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road , Hangzhou 310052, Zhejiang Province, China. 6198003@zju.edu.cn
Key Words	Crouzon syndrome; Craniosynostosis; Fibroblast growth factor receptor 2; Mutation; Fraternal twin; Case report
Core Tip	Crouzon syndrome (CS) is an autosomal dominant inherited craniofacial disorder caused by mutations in fibroblast growth factor receptor 2, but approximately 50% of cases result from de novo mutations. This syndrome has been rarely seen and evaluated in fraternal twins, only one of whom has CS. We presented a 6-year-old fraternal twin boy diagnosed with CS who had many caries and enamel hypomineralization in the oral cavity. The boy’s parents and his fraternal twin sister did not show any abnormalities indicating CS, so we hypothesize that the fraternal twin boy’s gene mutation arose from a de novo mutation.
Publish Date	2022-06-02 10:05
Citation	Li XJ, Su JM, Ye XW. Crouzon syndrome in a fraternal twin: A case report and review of the literature. World J Clin Cases 2022; 10(16): 5317-5323
URL	https://www.wjgnet.com/2307-8960/full/v10/i16/5317.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i16.5317

Full Article (PDF)	WJCC-10-5317.pdf
Full Article (Word)	WJCC-10-5317.docx
CARE Checklist–2016	68886-CARE-Checklist–2016-revision.pdf
Manuscript File	68886_Auto_Edited-YLC-Filipodia.docx
Answering Reviewers	68886-Answering reviewers.pdf
Audio Core Tip	68886-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	68886-Conflict-of-interest statement.pdf
Copyright License Agreement	68886-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	68886-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	68886-Language certificate.pdf
Peer-review Report	68886-Peer-review(s).pdf
Scientific Misconduct Check	68886-Bing-Chen YL-2.png
Scientific Editor Work List	68886-Scientific editor work list.pdf