Publication Name	World Journal of Gastroenterology
Manuscript ID	6891
Country	Spain

Received	2013-10-29 19:39
Peer-Review Started	2013-10-31 18:12
To Make the First Decision	2013-12-04 08:47
Return for Revision	2013-12-04 19:47
Revised	2013-12-23 07:49
Second Decision	2014-01-20 18:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-26 11:18
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Involvement of substance P and the NK-1 receptor in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Miguel Muñoz and Rafael Coveñas
Funding Agency and Grant Number
Corresponding Author	Dr. Miguel Muñoz, Virgen del Rocío University Hospital, Research Laboratory on Neuropeptides (IBIS), Unidad de Cuidados Intensivos Pediátricos Av. Manuel Siurot s/n, 41013 Seville, Spain. mmunoz@cica.es
Key Words	Pancreas; Substance P; Neurokinin-1 receptor antagonists; Apoptosis; Antitumor; Angiogenesis; Metastasis; Pancreatic cancer
Core Tip	The substance P (SP)/neurokinin-1 (NK-1) receptor system plays an important role in pancreatic cancer progression. Pancreatic cancer cells overexpress NK-1 receptors and SP promotes angiogenesis and the proliferation and the migration of pancreatic tumor cells. By contrast, NK-1 receptor antagonists, in a concentration-dependent manner, inhibit pancreatic cell proliferation (tumor cells die by apoptosis), have antiangiogenic properties in pancreatic cancer and block the migratory activity of pancreatic tumor cells. The antitumor action is mediated through the NK-1 receptor. Thus, the NK-1 receptor could be a new promising therapeutic target in pancreatic cancer and NK-1 receptor antagonists could improve pancreatic cancer treatment.
Publish Date	2014-03-06 14:13
Citation	Munoz M, Covenas R. Involvement of substance P and the NK-1 receptor in pancreatic cancer. World J Gastroenterol 2014; 20(9): 2321-2334
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2321.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2321

Full Article (PDF)	WJG-20-2321.pdf
Full Article (Word)	WJG-20-2321.doc
Manuscript File	6891-Review.docx
Answering Reviewers	6891-Answering reviews.pdf
Copyright License Agreement	6891-Copyright assignment.pdf
Peer-review Report	6891-Peer review(s).pdf
Scientific Editor Work List	6891-Scientific editor work list.doc