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Publication Name World Journal of Gastroenterology
Manuscript ID 6891
Country/Territory Spain
2013-10-29 19:39
Peer-Review Started
2013-10-31 18:12
To Make the First Decision
2013-12-04 08:47
Return for Revision
2013-12-04 19:47
2013-12-23 07:49
Second Decision
2014-01-20 18:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 19:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-26 11:18
Publish the Manuscript Online
2014-03-06 14:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Involvement of substance P and the NK-1 receptor in pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Miguel Muñoz and Rafael Coveñas
Funding Agency and Grant Number
Corresponding author Dr. Miguel Muñoz, Virgen del Rocío University Hospital, Research Laboratory on Neuropeptides (IBIS), Unidad de Cuidados Intensivos Pediátricos Av. Manuel Siurot s/n, 41013 Seville, Spain. mmunoz@cica.es
Keywords Pancreas; Substance P; Neurokinin-1 receptor antagonists; Apoptosis; Antitumor; Angiogenesis; Metastasis; Pancreatic cancer
Core Tip The substance P (SP)/neurokinin-1 (NK-1) receptor system plays an important role in pancreatic cancer progression. Pancreatic cancer cells overexpress NK-1 receptors and SP promotes angiogenesis and the proliferation and the migration of pancreatic tumor cells. By contrast, NK-1 receptor antagonists, in a concentration-dependent manner, inhibit pancreatic cell proliferation (tumor cells die by apoptosis), have antiangiogenic properties in pancreatic cancer and block the migratory activity of pancreatic tumor cells. The antitumor action is mediated through the NK-1 receptor. Thus, the NK-1 receptor could be a new promising therapeutic target in pancreatic cancer and NK-1 receptor antagonists could improve pancreatic cancer treatment.
Publish Date 2014-03-06 14:13
Citation Munoz M, Covenas R. Involvement of substance P and the NK-1 receptor in pancreatic cancer. World J Gastroenterol 2014; 20(9): 2321-2334
Url http://www.wjgnet.com/1007-9327/full/v20/i9/2321.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i9.2321
Full Article (PDF) WJG-20-2321.pdf
Full Article (Word) WJG-20-2321.doc
Manuscript File 6891-Review.docx
Answering Reviewers 6891-Answering reviews.pdf
Copyright License Agreement 6891-Copyright assignment.pdf
Peer-review Report 6891-Peer review(s).pdf
Scientific Editor Work List 6891-Scientific editor work list.doc