Publication Name	World Journal of Gastroenterology
Manuscript ID	6900
Country	Greece

Received	2013-10-29 20:11
Peer-Review Started	2013-11-01 10:54
First Decision by Editorial Office Director
Return for Revision	2013-12-02 16:00
Revised	2013-12-27 02:03
Publication Fee Transferred
Second Decision by Editor	2014-03-13 13:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-13 16:43
Articles in Press	2014-05-23 10:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-16 15:26
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Treatment of Helicobacter pylori infection: Meeting the challenge of antimicrobial resistance
Manuscript Source	Invited Manuscript
All Author List	Vasilios Papastergiou, Sotirios D Georgopoulos and Stylianos Karatapanis
Funding Agency and Grant Number
Corresponding Author	Stylianos Karatapanis, MD, PhD, Department of Internal Medicine, General Hospital of Rhodes, 10 Kalopetras Str, 85100 Rhodes, Greece. stylkar@otenet.gr
Key Words	Helicobacter pylori; Antibiotic resistance; Bismuth-quadruple; Concomitant; Sequential
Core Tip	Rising clarithromycin resistance has accounted for a dramatic decline in the efficacy of standard therapies for Helicobacter pylori (H. pylori) infection. Bismuth-quadruple, sequential, non-bismuth quadruple (concomitant), dual-concomitant (hybrid), and levofloxacin-based regimens are now recommended as preferred empirical treatments (> 90% efficacy). However, empiric treatment of H. pylori is likely to become more challenging as even these improved regimens are prone to the effect of antibiotic resistance. Individualized therapy appears as a reasonable future alternative, currently limited by the shortcomings of performing culture. Advances in the genotypic characterization of H. pylori therapeutic susceptibility are likely to revolutionize our approach to tailored treatment.
Publish Date	2014-08-07 10:34
Citation	Papastergiou V, Georgopoulos SD, Karatapanis S. Treatment of Helicobacter pylori infection: Meeting the challenge of antimicrobial resistance. World J Gastroenterol 2014; 20(29): 9898-9911
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9898.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9898

Full Article (PDF)	WJG-20-9898.pdf
Full Article (Word)	WJG-20-9898.doc
Manuscript File	6900-Review.docx
Answering Reviewers	6900-Answering reviewers.pdf
Copyright License Agreement	6900-Copyright assignment.pdf
Peer-review Report	6900-Peer reviewer(s).pdf
Scientific Editor Work List	6900-Scientific editor work list.doc