Publication Name	World Journal of Medical Genetics
Manuscript ID	6923
Country	Italy

Received	2013-10-29 22:23
Peer-Review Started	2013-10-30 20:14
To Make the First Decision	2013-12-25 17:58
Return for Revision	2013-12-30 16:22
Revised	2014-02-10 16:10
Second Decision	2014-02-18 12:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-18 12:31
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-12 22:38
Typeset the Manuscript	2014-05-27 18:57
Publish the Manuscript Online	2014-05-28 15:12

ISSN	2220-3184 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Osteopathia striata with cranial sclerosis, Wilms’ tumor and the WTX gene
Manuscript Source	Invited Manuscript
All Author List	Elisa Cattaneo, Sara Ciceri, Natascia Liberati, Paolo Radice, Luigi Tarani, Angelo Selicorni and Daniela Perotti
Funding Agency and Grant Number	Funding Agency Grant Number Italian Association for Cancer Research (AIRC) Fondazione Pierfranco e Luisa Mariani Associazione Bianca Garavaglia
Corresponding Author	Daniela Perotti, PhD, Molecular Bases of Genetic Risk and Genetic Testing Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milano, Italy. daniela.perotti@istitutotumori.mi.it
Key Words	Osteopathia striata with cranial sclerosis; Wilms’ tumor; WTX; Mutation; Genetics
Core Tip	Osteopathia striata with cranial sclerosis (OSCS), a condition often benign in females and severe and lethal in males, has a clinically heterogeneous presentation. Germline anomalies affecting the WTX gene, mapped to chromosome X, are causative of OSCS. Despite WTX mutations in Wilms’ tumor (WT) that closely mirror those identified in OSCS patients, individuals with OSCS do not develop WT. This is in contrast with other syndromic conditions, in which germline mutations or epimutations, also found as somatic events in sporadic WTs, predispose to WT development.
Publish Date	2014-05-28 15:12
Citation	Cattaneo E, Ciceri S, Liberati N, Radice P, Tarani L, Selicorni A, Perotti D. Osteopathia striata with cranial sclerosis, Wilms’ tumor and the WTX gene. World J Med Genet 2014; 4(2): 34-38
URL	http://www.wjgnet.com/2220-3184/full/v4/i2/34.htm
DOI	http://dx.doi.org/10.5496/wjmg.v4.i2.34

Full Article (PDF)	WJMG-4-34.pdf
Full Article (Word)	WJMG-4-34.doc
Manuscript File	6923-Review.docx
Answering Reviewers	6923-Answering reviewers.pdf
Copyright License Agreement	6923-Copyright assignment.pdf
Peer-review Report	6923-Peer review(s).pdf
Scientific Editor Work List	6923-Scientific editor work list.doc