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Articles Published Processes
1/15/2022 7:06:22 AM | Browse: 477 | Download: 845
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Received |
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2021-06-24 18:08 |
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Peer-Review Started |
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2021-06-24 18:11 |
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To Make the First Decision |
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Return for Revision |
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2021-07-31 04:30 |
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Revised |
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2021-08-22 14:07 |
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Second Decision |
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2021-11-22 03:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-25 02:38 |
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Articles in Press |
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2021-11-25 02:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-11-18 09:19 |
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Typeset the Manuscript |
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2022-01-07 03:55 |
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Publish the Manuscript Online |
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2022-01-15 07:06 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Review |
| Article Title |
Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis, transmission, and therapeutic evaluation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Udhaya Bharathy Saravanan, Mayurikaa Namachivayam, Rajesh Jeewon, Jian-Dong Huang and Siva Sundara Kumar Durairajan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| COVID Therapeutics, Department of Biotechnology, Government of India |
RefBT/PR4094/COT/142/20/2021 |
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| Corresponding Author |
Siva Sundara Kumar Durairajan, MSc, PhD, Associate Professor, Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Neelakudi, Tiruvarur 610005, India. d.sivasundarakumar@cutn.ac.in |
| Key Words |
Animal models; SARS-CoV-1; SARS-CoV-2; COVID-19; Mice; Hamster; Non-human primates; Pathogenesis; Transmission; Therapeutics |
| Core Tip |
In this manuscript we discuss the importance of various animal models of human pathogenic coronaviruses. Of which severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and SARS-CoV-1 were cited as pandemic and epidemic viruses by World Health Organization and SARS-CoV-2 of top most concern of public health. Due to the inadequate knowledge in analyzing the mode of action of coronavirus disease 2019 infection, we must be thoroughly familiarized with the available animal models. Therefore, we have discussed the pros and cons of various animal models, and emphasized the use of humanized mouse to study the biology of viral disease because it is convenient mimic human immune system in humanized mice. |
| Publish Date |
2022-01-15 07:06 |
| Citation |
Saravanan UB, Namachivayam M, Jeewon R, Huang JD, Durairajan SSK. Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis, transmission, and therapeutic evaluation. World J Virol 2022; 11(1): 40-56 |
| URL |
https://www.wjgnet.com/2220-3249/full/v11/i1/40.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v11.i1.40 |
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