Publication Name	World Journal of Diabetes
Manuscript ID	69536
Country	Brazil

Received	2021-07-03 19:46
Peer-Review Started	2021-07-03 19:51
To Make the First Decision
Return for Revision	2021-07-28 04:58
Revised	2021-08-01 21:31
Second Decision	2021-12-29 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-31 22:26
Articles in Press	2021-12-31 22:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-12-24 15:00
Typeset the Manuscript	2022-01-07 06:41
Publish the Manuscript Online	2022-01-11 06:48

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Gut microbiota-derived metabolites are novel targets for improving insulin resistance
Manuscript Source	Invited Manuscript
All Author List	Rosana MC Bastos and Érika B Rangel
ORCID	Author(s) ORCID Number Rosana MC Bastos http://orcid.org/0000-0002-4348-1487 Érika B Rangel http://orcid.org/0000-0003-0982-2484
Funding Agency and Grant Number	Funding Agency Grant Number São Paulo Research Foundation 2013/19560-6 São Paulo Research Foundation 2017/23195-2 EFSD (European Foundation for the Study of Diabetes)/Sanofi
Corresponding Author	Érika B Rangel, MD, PhD, Assistant Professor, Senior Scientist, /, Hospital Israelita Albert Einstein, Av Albert Einstein 627, Building A, 2SS, São Paulo 05652-001, SP, Brazil. erikabr@uol.com.br
Key Words	Insulin resistance; Gut microbiota; Metabolites; Host metabolism; Metabolic organs; Novel targets
Core Tip	The gut-microbiota-derived metabolites play a key role in metabolic diseases. Insulin signaling pathways are directly targeted by these metabolites, as they promote an increase in glucose uptake and lipid oxidation in skeletal muscle; a decrease in lipogenesis and gluconeogenesis associated with an increase in lipid oxidation in the liver; and an improvement in thermogenesis and inflammation in the adipose tissue. Collectively, these findings pave the way for the development of novel drugs or for investigation of the therapeutic potential of drugs currently used to treat insulin resistance, targeting the gut-microbiota-derived metabolites.
Publish Date	2022-01-11 06:48
Citation	Bastos RM, Rangel ÉB. Gut microbiota-derived metabolites are novel targets for improving insulin resistance . World J Diabetes 2022; 13(1): 65-69
URL	https://www.wjgnet.com/1948-9358/full/v13/i1/65.htm
DOI	https://dx.doi.org/10.4239/wjd.v13.i1.65

Full Article (PDF)	WJD-13-65.pdf
Full Article (Word)	WJD-13-65.docx
Manuscript File	69536_Auto_Edited-CCG-Kerr C.docx
Answering Reviewers	69536-Answering reviewers.pdf
Audio Core Tip	69536-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	69536-Conflict-of-interest statement.pdf
Copyright License Agreement	69536-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	69536-Grant application form(s).pdf
Peer-review Report	69536-Peer-review(s).pdf
Scientific Misconduct Check	69536-Bing-Gao CC-2.png
Scientific Editor Work List	69536-Scientific editor work list.pdf
CrossCheck Report	69536-CrossCheck report.pdf